HCLS1 Products
(Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))
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This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].
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Featured HCLS1 Categories
HCLS1 Antibodies
High quality antibodies with extensive validation data.
HCLS1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HCLS1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), PLA, RNAi
Validations
- (7)
Cat. No.
ABIN516371
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB, IHC
Validations
- (1)
- (9)
Cat. No.
ABIN2777503
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (5)
Cat. No.
ABIN516375
Quantity
100 μg
Datasheet
Datasheet
Recommended HCLS1 ELISA Kits
Recommended HCLS1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306429
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306431
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Human Cells
Validations
Cat. No.
ABIN4371214
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our HCLS1 products
: "Role of cortactin homolog HS1 in transendothelial migration of natural killer cells." in: PLoS ONE, Vol. 10, Issue 2, pp. e0118153, (2015) (PubMed).: "SDF1α-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells." in: European journal of immunology, Vol. 45, Issue 2, pp. 551-61, (2015) (PubMed).
: "Endothelial cell dysfunction and cytoskeletal changes associated with repression of p16(INK4a) during immortalization." in: Oncogene, Vol. 31, Issue 46, pp. 4815-27, (2012) (PubMed).
: "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells." in: The Biochemical journal, Vol. 364, Issue Pt 1, pp. 41-7, (2002) (PubMed).
: "LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck." in: The EMBO journal, Vol. 14, Issue 14, pp. 3403-14, (1995) (PubMed).
: "Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 16, pp. 7302-6, (1995) (PubMed).
: "Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 8, pp. 3631-5, (1993) (PubMed).
Synonyms and alternative names related to HCLS1
hematopoietic cell-specific Lyn substrate 1 (HCLS1), hematopoietic cell specific Lyn substrate 1 (Hcls1), hematopoietic lineage cell-specific protein-like (LOC100223649), hematopoietic cell-specific Lyn substrate 1 (hcls1), hematopoietic cell-specific Lyn substrate 1 (Hcls1), AW213261, CTTNL, HCLS1, hcls1, HS1, si:dkey-9a20.6, wu:fk96b08, zgc:154014Protein level used designations for HCLS1
- hematopoietic lineage cell-specific protein
- lckBP1
- p75
- hematopoietic cell-specific LYN substrate 1
- hematopoietic cell-specific Lyn substrate 1
- hematopoietic lineage cell-specific protein-like
- Hematopoietic lineage cell-specific protein
- fk96b08
- uncharacterized protein LOC563056
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