HBEGF Products
(Heparin-Binding EGF-Like Growth Factor (HBEGF))
Categories
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
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Featured HBEGF Categories
HBEGF Antibodies
High quality antibodies with extensive validation data.
HBEGF ELISA Kits
Reliable ELISA kits for a wide range of species.
HBEGF Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HBEGF Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IF (cc), IHC (p)
Validations
- (1)
- (4)
Cat. No.
ABIN701050
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7433663
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IP, ICC, IF
Validations
- (4)
- (4)
Cat. No.
ABIN2451994
Quantity
50 μg
Datasheet
Datasheet
Recommended HBEGF ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6956482
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6956483
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6956484
Quantity
96 tests
Datasheet
Datasheet
Recommended HBEGF Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123301
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7092863
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7092865
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HBEGF products
: "Eckol Alleviates Intestinal Dysfunction during Suckling-to-Weaning Transition via Modulation of PDX1 and HBEGF." in: International journal of molecular sciences, Vol. 21, Issue 13, (2020) (PubMed).: "ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway." in: Biomedicine & pharmacotherapy, Vol. 97, pp. 1066-1077, (2018) (PubMed).
: "CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors. ..." in: Nature communications, Vol. 8, Issue 1, pp. 286, (2018) (PubMed).
: "Heparin-binding epidermal growth factor contributes to COPD disease severity by modulating airway fibrosis and pulmonary epithelial-mesenchymal transition." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 98, Issue 9, pp. 1159-1169, (2018) (PubMed).
: "GC1118, an Anti-EGFR Antibody with a Distinct Binding Epitope and Superior Inhibitory Activity against High-Affinity EGFR Ligands." in: Molecular cancer therapeutics, Vol. 15, Issue 2, pp. 251-63, (2016) (PubMed).
: "Heterogeneity of Notch signaling in astrocytes and the effects of GFAP and vimentin deficiency." in: Journal of neurochemistry, (2015) (PubMed).
: "A novel method for assessing bladder-related pain reveals the involvement of nerve growth factor in pain associated with cyclophosphamide-induced chronic cystitis in mice." in: European journal of pain (London, England), Vol. 20, Issue 1, pp. 79-91, (2015) (PubMed).
: "Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation." in: PLoS ONE, Vol. 10, Issue 8, pp. e0134176, (2015) (PubMed).
: "Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers." in: PLoS ONE, Vol. 9, Issue 5, pp. e97771, (2015) (PubMed).
: "TACE/ADAM17 is essential for oligodendrocyte development and CNS myelination." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 36, pp. 11884-96, (2014) (PubMed).
Synonyms and alternative names related to HBEGF
heparin-binding EGF-like growth factor b (hbegfb), heparin binding EGF like growth factor (HBEGF), Heparin-binding EGF-like growth factor (hbegf), heparin-binding EGF-like growth factor a (hbegfa), heparin-binding EGF-like growth factor (Hbegf), AW047313, DTR, Dtr, DTS, Dts, DTSF, GFHB, Hb-egf, HB-EGF, hbegf, HBEGF, HEGFL, Hegfl, zgc:165443, zgc:175091Protein level used designations for HBEGF
- proheparin-binding EGF-like growth factor
- heparin-binding EGF-like growth factor
- Heparin-binding EGF-like growth factor
- diphtheria toxin receptor (heparin-binding EGF-like growth factor)
- diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)
- heparin-binding epidermal growth factor
- Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)
- heparin binding epidermal growth factor-like growth factor
- heparin-binding epidermal -growth - like growth factor
- heparin-binding epidermal -growth factor
- diphtheria toxin receptor
- heparin-binding epidermal growth factor-like growth factor
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