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Hairy and Enhancer of Split 4 Products

(Hairy and Enhancer of Split 4 (HES4))

Categories

Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Promotes floor plate development and prechordal plate development. Required for lens development as early as the stage of lens field formation, partly through regulation of gene expression of the cell cycle inhibitor cdknx/p27(xic1). Required for formation of the neural crest downstream of multiple signaling pathways, and acts at the neural plate border via both DNA-binding dependent and independent mechanisms. Also acts via repressor- dependent and repressor-independent mechanisms in early gastrulae to establish the prospective anterior prechordal mesoderm identity in the Spemann organizer\; induces specific genes independently from direct transcriptional regulation, and represses the genes specific for neighboring tissues through direct transcriptional repression. Modulates lateral inhibition during notch signaling and regulates the cell context dependent effects of notch (which can have inhibitory, permissive or enhancing roles in muscle or neural differentiation). Inhibits myogenesis (By similarity).

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Featured Hairy and Enhancer of Split 4 Categories

Hairy and Enhancer of Split 4 Antibodies

High quality antibodies with extensive validation data.

Hairy and Enhancer of Split 4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Hairy and Enhancer of Split 4 Antibodies

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Reactivity Human
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Latest Publications for our Hairy and Enhancer of Split 4 products

El Yakoubi, Borday, Hamdache, Parain, Tran, Vleminckx, Perron, Locker: "Hes4 controls proliferative properties of neural stem cells during retinal ontogenesis." in: Stem cells (Dayton, Ohio), Vol. 30, Issue 12, pp. 2784-95, (2012) (PubMed).

Synonyms and alternative names related to Hairy and Enhancer of Split 4

hes family bHLH transcription factor 4 (HES4), hes family bHLH transcription factor 4 (hes4), hes family bHLH transcription factor 4 L homeolog (hes4.L), hes family bHLH transcription factor 4 S homeolog (hes4.S), bHLHb42, hairy2, hairy2a, hairy2b, hes1, hes4a, hes4b, Xhairy2, XHairy2a, Xhairy2a, Xhairy2b

Protein level used designations for Hairy and Enhancer of Split 4

  • bHLH factor Hes4
  • class B basic helix-loop-helix protein 42
  • hHES4
  • transcription factor HES-4
  • Protein hairy-2
  • hairy and enhancer of split 1
  • transcription factor HES-4-B
  • hairy2b
  • Protein hairy-2a
  • Hairy and enhancer of split 4-B
  • transcription factor HES-4-A
  • Hairy and enhancer of split 4-A
  • basic-helix-loop-helix transcription factor hairy2
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