Hairy and Enhancer of Split 4 Products
(Hairy and Enhancer of Split 4 (HES4))
Categories
Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Promotes floor plate development and prechordal plate development. Required for lens development as early as the stage of lens field formation, partly through regulation of gene expression of the cell cycle inhibitor cdknx/p27(xic1). Required for formation of the neural crest downstream of multiple signaling pathways, and acts at the neural plate border via both DNA-binding dependent and independent mechanisms. Also acts via repressor- dependent and repressor-independent mechanisms in early gastrulae to establish the prospective anterior prechordal mesoderm identity in the Spemann organizer\; induces specific genes independently from direct transcriptional regulation, and represses the genes specific for neighboring tissues through direct transcriptional repression. Modulates lateral inhibition during notch signaling and regulates the cell context dependent effects of notch (which can have inhibitory, permissive or enhancing roles in muscle or neural differentiation). Inhibits myogenesis (By similarity).
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Featured Hairy and Enhancer of Split 4 Categories
Hairy and Enhancer of Split 4 Antibodies
High quality antibodies with extensive validation data.
Hairy and Enhancer of Split 4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Hairy and Enhancer of Split 4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
Cat. No.
ABIN1781859
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Human, Monkey
Application
WB
Validations
- (1)
Cat. No.
ABIN202082
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN202081
Quantity
100 μL
Datasheet
Datasheet
Recommended Hairy and Enhancer of Split 4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306551
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3081428
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2722664
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our Hairy and Enhancer of Split 4 products
: "Hes4 controls proliferative properties of neural stem cells during retinal ontogenesis." in: Stem cells (Dayton, Ohio), Vol. 30, Issue 12, pp. 2784-95, (2012) (PubMed).Synonyms and alternative names related to Hairy and Enhancer of Split 4
hes family bHLH transcription factor 4 (HES4), hes family bHLH transcription factor 4 (hes4), hes family bHLH transcription factor 4 L homeolog (hes4.L), hes family bHLH transcription factor 4 S homeolog (hes4.S), bHLHb42, hairy2, hairy2a, hairy2b, hes1, hes4a, hes4b, Xhairy2, XHairy2a, Xhairy2a, Xhairy2bProtein level used designations for Hairy and Enhancer of Split 4
- bHLH factor Hes4
- class B basic helix-loop-helix protein 42
- hHES4
- transcription factor HES-4
- Protein hairy-2
- hairy and enhancer of split 1
- transcription factor HES-4-B
- hairy2b
- Protein hairy-2a
- Hairy and enhancer of split 4-B
- transcription factor HES-4-A
- Hairy and enhancer of split 4-A
- basic-helix-loop-helix transcription factor hairy2
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