GRB10 Products
(Growth Factor Receptor-Bound Protein 10 (GRB10))
Categories
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010].
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Featured GRB10 Categories
GRB10 Antibodies
High quality antibodies with extensive validation data.
GRB10 ELISA Kits
Reliable ELISA kits for a wide range of species.
GRB10 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GRB10 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
- (7)
Cat. No.
ABIN7436048
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN561124
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN3184930
Quantity
100 μL
Datasheet
Datasheet
Recommended GRB10 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967246
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956335
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380446
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended GRB10 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355698
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355696
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7398446
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our GRB10 products
: "Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases." in: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10475-84, (1998) (PubMed).: "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains." in: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2659-67, (1997) (PubMed).
: "Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma." in: The Journal of biological chemistry, Vol. 272, Issue 46, pp. 29104-12, (1997) (PubMed).
: "Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling." in: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22506-13, (1996) (PubMed).
: "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 22, pp. 10287-91, (1995) (PubMed).
Synonyms and alternative names related to GRB10
growth factor receptor bound protein 10 (GRB10), growth factor receptor-bound protein 10a (grb10a), growth factor receptor bound protein 10 (grb10), growth factor receptor bound protein 10 L homeolog (grb10.L), growth factor receptor-bound protein 10 (LOC100434903), growth factor receptor bound protein 10 (Grb10), 5730571D09Rik, AI325020, grb-10, Grb-10, grb-ir, GRB-IR, grb10, GRB10, irbp, IRBP, LOC100224775, meg1, Meg1, MEG1, mKIAA0207, RGD1566234, rss, RSS, zgc:91987Protein level used designations for GRB10
- growth factor receptor-bound protein 10
- zgc:91987growth factor receptor-bound protein 10
- growth factor receptor-bound protein 10-like
- GRB10 adapter protein
- maternally expressed gene 1 protein
- GRB10 adaptor protein
- insulin receptor-binding protein Grb-IR
- maternally expressed gene 1
- adapter protein
- binds to insulin receptor and IGF1R
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