Granulin Products
(Granulin (GRN))
Categories
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
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Featured Granulin Categories
Granulin Antibodies
High quality antibodies with extensive validation data.
Granulin ELISA Kits
Reliable ELISA kits for a wide range of species.
Granulin Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Granulin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7440077
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7440863
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ICC, IF, IHC (p)
Validations
- (4)
Cat. No.
ABIN2854868
Quantity
100 μL
Datasheet
Datasheet
Recommended Granulin ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (6)
Cat. No.
ABIN6730966
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
Cat. No.
ABIN6967189
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956290
Quantity
96 tests
Datasheet
Datasheet
Recommended Granulin Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (3)
- (1)
Cat. No.
ABIN1355792
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355791
Quantity
2 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123193
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our Granulin products
: "GRN, NOTCH3, FN1, and PINK1 expression in eutopic endometrium - potential biomarkers in the detection of endometriosis - a pilot study." in: Journal of assisted reproduction and genetics, Vol. 37, Issue 11, pp. 2723-2732, (2020) (PubMed).: "The effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status." in: Endokrynologia Polska, Vol. 70, Issue 3, pp. 255-259, (2019) (PubMed).
: "Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 12, pp. E2849-E2858, (2018) (PubMed).
: "Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations." in: eNeuro, Vol. 4, Issue 4, (2018) (PubMed).
: "Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer." in: Oncotarget, Vol. 8, Issue 16, pp. 26323-26333, (2018) (PubMed).
: "CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. ..." in: EMBO molecular medicine, Vol. 10, Issue 12, (2018) (PubMed).
: "Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness." in: Oncogene, Vol. 34, Issue 14, pp. 1853-64, (2015) (PubMed).
: "The molecular basis for development of proinflammatory autoantibodies to progranulin." in: Journal of autoimmunity, Vol. 61, pp. 17-28, (2015) (PubMed).
: "Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment." in: Journal of neuroinflammation, Vol. 12, pp. 200, (2015) (PubMed).
: "Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population." in: PLoS ONE, Vol. 9, Issue 8, pp. e105583, (2014) (PubMed).
Synonyms and alternative names related to Granulin
granulin precursor (GRN), granulin a (grna), Granulins (grn), granulin L homeolog (grn.L), granulin (granulin), granulin (ORF1 granulin), granulin precursor (Grn), granulin (Grn), acrogranin, CLN11, DKFZp459H066, epithelin, GEP, GP88, GRN, grn, MGC53354, PCDGF, PEPI, PGRN, wu:fb11g12, wu:fj18f05Protein level used designations for Granulin
- granulin
- granulin-a
- zfPGRN-A
- Granulins
- PC cell-derived growth factor
- acrogranin
- granulin-epithelin
- granulins
- proepithelin
- progranulin
- PCDGF
- PEPI
- acrogranulin
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