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Granulin Products

(Granulin (GRN))

Categories

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].

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Featured Granulin Categories

Granulin Antibodies

High quality antibodies with extensive validation data.

Granulin ELISA Kits

Reliable ELISA kits for a wide range of species.

Granulin Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Granulin Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7440077
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7440863
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ICC, IF, IHC (p)
Validations
  • (4)
Cat. No. ABIN2854868
Quantity 100 μL
Datasheet Datasheet

Recommended Granulin ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (6)
Cat. No. ABIN6730966
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
  • (1)
Cat. No. ABIN6967189
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956290
Quantity 96 tests
Datasheet Datasheet

Recommended Granulin Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (3)
  • (1)
Cat. No. ABIN1355792
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1355791
Quantity 2 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123193
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our Granulin products

Holzer, Machado Weber, Marshall, Freis, Jauckus, Strowitzki, Germeyer: "GRN, NOTCH3, FN1, and PINK1 expression in eutopic endometrium - potential biomarkers in the detection of endometriosis - a pilot study." in: Journal of assisted reproduction and genetics, Vol. 37, Issue 11, pp. 2723-2732, (2020) (PubMed).

Kan, Gorkem: "The effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status." in: Endokrynologia Polska, Vol. 70, Issue 3, pp. 255-259, (2019) (PubMed).

Nguyen, Nguyen, Zhang, Devireddy, Zhou, Karydas, Xu, Miller, Rigo, Ferguson, Huang, Walther, Farese: "Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 12, pp. E2849-E2858, (2018) (PubMed).

Holler, Taylor, Deng, Kukar: "Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations." in: eNeuro, Vol. 4, Issue 4, (2018) (PubMed).

Wang, Yang, Tian, Gao, Shen, Ren, Li, Jiang, Dong: "Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer." in: Oncotarget, Vol. 8, Issue 16, pp. 26323-26333, (2018) (PubMed).

Suárez-Calvet, Capell, Araque Caballero, Morenas-Rodríguez, Fellerer, Franzmeier, Kleinberger, Eren, Deming, Piccio, Karch, Cruchaga, Paumier, Bateman, Fagan, Morris, Levin, Danek, Jucker, Masters et al.: "CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. ..." in: EMBO molecular medicine, Vol. 10, Issue 12, (2018) (PubMed).

Bandey, Chiou, Huang, Tsai, Tu: "Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness." in: Oncogene, Vol. 34, Issue 14, pp. 1853-64, (2015) (PubMed).

Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: "The molecular basis for development of proinflammatory autoantibodies to progranulin." in: Journal of autoimmunity, Vol. 61, pp. 17-28, (2015) (PubMed).

Zhou, Xie, Wang, Zhang, Chen, Zhang, Wu, Wei, Ding, Hang, Zhou, Shi: "Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment." in: Journal of neuroinflammation, Vol. 12, pp. 200, (2015) (PubMed).

Qu, Wang, Deng, Wei, Deng: "Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population." in: PLoS ONE, Vol. 9, Issue 8, pp. e105583, (2014) (PubMed).

Synonyms and alternative names related to Granulin

granulin precursor (GRN), granulin a (grna), Granulins (grn), granulin L homeolog (grn.L), granulin (granulin), granulin (ORF1 granulin), granulin precursor (Grn), granulin (Grn), acrogranin, CLN11, DKFZp459H066, epithelin, GEP, GP88, GRN, grn, MGC53354, PCDGF, PEPI, PGRN, wu:fb11g12, wu:fj18f05

Protein level used designations for Granulin

  • granulin
  • granulin-a
  • zfPGRN-A
  • Granulins
  • PC cell-derived growth factor
  • acrogranin
  • granulin-epithelin
  • granulins
  • proepithelin
  • progranulin
  • PCDGF
  • PEPI
  • acrogranulin
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