GRAF Products
(rho GTPase Activating Protein 26 (ARHGAP26))
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Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
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Featured GRAF Categories
GRAF Antibodies
High quality antibodies with extensive validation data.
GRAF Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
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Latest Publications for our GRAF products
: "Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia." in: Journal of neuroinflammation, Vol. 11, pp. 206, (2015) (PubMed).: "Novel signatures of cancer-associated fibroblasts." in: International journal of cancer, Vol. 133, Issue 2, pp. 286-93, (2013) (PubMed).
: "Expression of cyclins-B and cyclins-e in individual molt-4 cells and in stimulated human-lymphocytes during their progression through the cell-cycle." in: International journal of oncology, Vol. 3, Issue 6, pp. 1037-42, (2011) (PubMed).
: "A new Purkinje cell antibody (anti-Ca) associated with subacute cerebellar ataxia: immunological characterization." in: Journal of neuroinflammation, Vol. 7, pp. 21, (2010) (PubMed).
: "Rho proteins, mental retardation and the cellular basis of cognition." in: Trends in neurosciences, Vol. 25, Issue 4, pp. 191-9, (2002) (PubMed).
: "The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 16, pp. 9168-73, (2000) (PubMed).
: "Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F." in: Nature, Vol. 355, Issue 6356, pp. 176-9, (1992) (PubMed).
Synonyms and alternative names related to GRAF
Rho GTPase activating protein 26 (ARHGAP26), Rho GTPase activating protein 26 (Arhgap26), 1810044B20Rik, 2610010G17Rik, 4933432P15Rik, AI853435, ARHGAP26, GRAF, GRAF1, mKIAA0621, OPHN1L, OPHN1L1Protein level used designations for GRAF
- Rho GTPase activating protein 26
- rho GTPase-activating protein 26-like
- GTPase regulator associated with focal adhesion kinase pp125(FAK)
- oligophrenin-1-like protein
- rho GTPase-activating protein 26
- rho-type GTPase-activating protein 26
- GTPase regulator associated with focal adhesion kinase
- rhoGap protein
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