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GPX4 Products

(Glutathione Peroxidase 4 (GPX4))
Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists\; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. [provided by RefSeq, Jul 2008].

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Featured GPX4 Categories

GPX4 Antibodies

High quality antibodies with extensive validation data.

GPX4 ELISA Kits

Reliable ELISA kits for a wide range of species.

GPX4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GPX4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, IF
Validations
  • (1)
  • (8)
Cat. No. ABIN3015730
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (9)
Cat. No. ABIN7438652
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7439558
Quantity 100 μL
Datasheet Datasheet

Recommended GPX4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956199
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6975523
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6975657
Quantity 96 tests
Datasheet Datasheet

Recommended GPX4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123131
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7403591
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7404995
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our GPX4 products

Wang, Zheng, Zhang, Zhao, Wang, Wang, Shang, Barasch, Qiu: "Physiological functions of ferroportin in the regulation of renal iron recycling and ischemic acute kidney injury." in: American journal of physiology. Renal physiology, Vol. 315, Issue 4, pp. F1042-F1057, (2018) (PubMed).

Agbor, Demma, Mrsny, Castillo, Boll, McCormick: "The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration." in: Cellular microbiology, Vol. 16, Issue 9, pp. 1339-53, (2014) (PubMed).

Papp, Lu, Bolderson, Boucher, Singh, Holmgren, Khanna: "SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress." in: Antioxidants & redox signaling, Vol. 12, Issue 7, pp. 797-808, (2010) (PubMed).

Schoenmakers, Agostini, Mitchell, Schoenmakers, Papp, Rajanayagam, Padidela, Ceron-Gutierrez, Doffinger, Prevosto, Luan, Montano, Lu, Castanet, Clemons, Groeneveld, Castets, Karbaschi, Aitken, Dixon et al.: "Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. ..." in: The Journal of clinical investigation, Vol. 120, Issue 12, pp. 4220-35, (2010) (PubMed).

Blackinton, Kumaran, van der Brug, Ahmad, Olson, Galter, Lees, Bandopadhyay, Cookson: "Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease." in: Neuroscience letters, Vol. 452, Issue 1, pp. 8-11, (2009) (PubMed).

Su, Novoselov, Sun, Moustafa, Zhou, Oko, Hatfield, Gladyshev: "Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation." in: The Journal of biological chemistry, Vol. 280, Issue 28, pp. 26491-8, (2005) (PubMed).

Nakagawa: "Role of mitochondrial phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an antiapoptotic factor." in: Biological & pharmaceutical bulletin, Vol. 27, Issue 7, pp. 956-60, (2004) (PubMed).

Takebe, Yarimizu, Saito, Hayashi, Nakamura, Yodoi, Nagasawa, Takahashi: "A comparative study on the hydroperoxide and thiol specificity of the glutathione peroxidase family and selenoprotein P." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 41254-8, (2002) (PubMed).

Synonyms and alternative names related to GPX4

glutathione peroxidase 4 (GPX4), glutathione peroxidase 4 (Gpx4), glutathione peroxidase 4a (gpx4a), 1700027O09Rik, ATGPX4, cb563, cb691, F11L15.5, glutathione peroxidase 4, GP-GPx4, GPx-4, gpx-4, GSHPx-4, MCSP, mtPHGPx, PHGPx, Phgpx, PHGPxa, sb:cb563, snGPx, snGpx, snPHGPx, wu:fb82e03, zgc:92253

Protein level used designations for GPX4

  • phospholipid hydroperoxidase
  • phospholipid hydroperoxide glutathione peroxidase, mitochondrial
  • sperm nucleus glutathione peroxidase
  • GSHPx-4
  • phospholipid hydroperoxide glutathione peroxidase, nuclear
  • glutathione peroxidase 4
  • GPx-4
  • sperm nuclei glutathione peroxidase
  • glutathione peroxidase 4 (phospholipid hydroperoxidase)
  • phospholipid hydroperoxide glutathione peroxidase
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