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GPR68 Products

(G Protein-Coupled Receptor 68 (GPR68))

Categories

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Function also as a metastasis suppressor gene in prostate cancer (By similarity).

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Featured GPR68 Categories

GPR68 Antibodies

High quality antibodies with extensive validation data.

Recommended GPR68 Antibodies

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Reactivity
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Quantity
Datasheet
Reactivity Human
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Cat. No. ABIN7162351
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
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Cat. No. ABIN1048863
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Source Tobacco (Nicotiana tabacum)
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Latest Publications for our GPR68 products

Wei, Jacobs, Becker, Glitsch: "Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 34, pp. 10738-43, (2015) (PubMed).

Frick, Krieger, Nehrke, Bushinsky: "Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 2, pp. 305-13, (2009) (PubMed).

Singh, Berk, Oates, Zhao, Tan, Jiang, Zhou, Kirmani, Steinmetz, Lindner, Xu: "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer." in: Journal of the National Cancer Institute, Vol. 99, Issue 17, pp. 1313-27, (2007) (PubMed).

Komarova, Pereverzev, Shum, Sims, Dixon: "Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 7, pp. 2643-8, (2005) (PubMed).

Mogi, Tomura, Tobo, Wang, Damirin, Kon, Komachi, Hashimoto, Sato, Okajima: "Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation." in: Journal of pharmacological sciences, Vol. 99, Issue 2, pp. 160-7, (2005) (PubMed).

Synonyms and alternative names related to GPR68

G protein-coupled receptor 68 (GPR68), G protein-coupled receptor 68 (LOC100348269), G protein-coupled receptor 68 (Gpr68), BB131428, GPR12A, GPR68, OGR1, Ogr1

Protein level used designations for GPR68

  • G protein-coupled receptor 68
  • ovarian cancer G-protein coupled receptor 1-like
  • G-protein coupled receptor 68
  • ovarian cancer G protein-coupled receptor, 1
  • ovarian cancer G-protein coupled receptor 1
  • sphingosylphosphorylcholine receptor
  • bRGR1
  • g protein-coupled receptor RGR1
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