GPR68 Products
(G Protein-Coupled Receptor 68 (GPR68))
Categories
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Function also as a metastasis suppressor gene in prostate cancer (By similarity).
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Featured GPR68 Categories
GPR68 Antibodies
High quality antibodies with extensive validation data.
Recommended GPR68 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7162351
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application
IHC, IHC (p), IF, ICC
Validations
- (1)
- (2)
Cat. No.
ABIN1048863
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7162350
Quantity
100 μL
Datasheet
Datasheet
Recommended GPR68 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Mammalian Cells
Validations
Cat. No.
ABIN7538286
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3124580
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3115033
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our GPR68 products
: "Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 34, pp. 10738-43, (2015) (PubMed).: "Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 2, pp. 305-13, (2009) (PubMed).
: "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer." in: Journal of the National Cancer Institute, Vol. 99, Issue 17, pp. 1313-27, (2007) (PubMed).
: "Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 7, pp. 2643-8, (2005) (PubMed).
: "Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation." in: Journal of pharmacological sciences, Vol. 99, Issue 2, pp. 160-7, (2005) (PubMed).
Synonyms and alternative names related to GPR68
G protein-coupled receptor 68 (GPR68), G protein-coupled receptor 68 (LOC100348269), G protein-coupled receptor 68 (Gpr68), BB131428, GPR12A, GPR68, OGR1, Ogr1Protein level used designations for GPR68
- G protein-coupled receptor 68
- ovarian cancer G-protein coupled receptor 1-like
- G-protein coupled receptor 68
- ovarian cancer G protein-coupled receptor, 1
- ovarian cancer G-protein coupled receptor 1
- sphingosylphosphorylcholine receptor
- bRGR1
- g protein-coupled receptor RGR1
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