GNAS Products
(GNAS Complex Locus (GNAS))
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This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012].
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Featured GNAS Categories
GNAS Antibodies
High quality antibodies with extensive validation data.
GNAS ELISA Kits
Reliable ELISA kits for a wide range of species.
GNAS Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GNAS Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (6)
Cat. No.
ABIN5542322
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB, IHC
Validations
- (2)
- (9)
Cat. No.
ABIN2775542
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, FACS, IHC (p)
Validations
- (5)
Cat. No.
ABIN656989
Quantity
400 μL
Datasheet
Datasheet
Recommended GNAS ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1135881
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1135882
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1135883
Quantity
96 tests
Datasheet
Datasheet
Recommended GNAS Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123179
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355349
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3080985
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our GNAS products
: "Gγ and Gα Identity Dictate a G-Protein Heterotrimer Plasma Membrane Targeting." in: Cells, Vol. 8, Issue 10, (2019) (PubMed).: "Recognition-induced covalent capturing and labeling as a general strategy for protein detection." in: Biosensors & bioelectronics, Vol. 80, pp. 560-5, (2016) (PubMed).
: "Differential effects of antidepressants escitalopram versus lithium on Gs alpha membrane relocalization." in: BMC neuroscience, Vol. 16, pp. 40, (2015) (PubMed).
: "APOA-I: a possible novel biomarker for metabolic side effects in first episode schizophrenia." in: PLoS ONE, Vol. 9, Issue 4, pp. e93902, (2014) (PubMed).
: "Biologic effects of dopamine on tumor vasculature in ovarian carcinoma." in: Neoplasia (New York, N.Y.), Vol. 15, Issue 5, pp. 502-10, (2013) (PubMed).
: "Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 304, Issue 11, pp. G1013-24, (2013) (PubMed).
: "The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical G??-dependent modulation of TRPV1 channel." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 35, pp. 11942-55, (2012) (PubMed).
: "The G?3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein." in: Cellular signalling, Vol. 24, Issue 12, pp. 2349-59, (2012) (PubMed).
: "Chronic sympathetic activation promotes downregulation of ?-adrenoceptor-mediated effects in the guinea pig heart independently of structural remodeling and systolic dysfunction." in: Pflügers Archiv : European journal of physiology, Vol. 462, Issue 4, pp. 529-43, (2011) (PubMed).
: "Prevalence of TSH receptor and Gsalpha mutations in 45 autonomously functioning thyroid nodules in Japan." in: Endocrine journal, Vol. 56, Issue 6, pp. 791-8, (2009) (PubMed).
Synonyms and alternative names related to GNAS
GNAS complex locus (GNAS), guanine nucleotide-binding protein G(s) subunit alpha (LOC694289), guanine nucleotide-binding protein G(s) subunit alpha (LOC469986), GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas), GNAS complex locus S homeolog (gnas.S), GNAS complex locus (Gnas), GNAS complex locus (gnas), neuroendocrine secretory protein 55-like (LOC100346323), guanine nucleotide-binding protein G(s) subunit alpha (LOC100442753), guanine nucleotide-binding protein G(s) subunit alpha (LOC100732436), 5530400H20Rik, A930027G11Rik, AHO, C20orf45, C130027O20Rik, G-alpha-S, G-alpha-s, Galphas, gnal, GNAS, Gnas, gnas-a, GNAS1, Gnas1, Gnasxl, Gnpas, GPSA, GSA, Gsa, GSP, NESP, Nesp, Nesp55, Nespl, Oed-Sml, Oedsml, P1, P2, P3, PHP1A, PHP1B, PHP1C, POH, PORGSA1Protein level used designations for GNAS
- adenylate cyclase-stimulating G alpha protein
- alternative gene product encoded by XL-exon
- extra large alphas protein
- guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
- guanine nucleotide regulatory protein
- guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
- neuroendocrine secretory protein
- protein ALEX
- secretogranin VI
- GNAS complex locus
- GTP-binding regulatory protein alpha subunit exon 1
- guanine nucleotide binding protein, alpha stimulating activity polypeptide 1
- guanine nucleotide-binding protein G(s) subunit alpha
- stimulatory GTP binding protein
- alpha-stimulatory subunit of GTP-binding protein
- guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1
- Gs alpha subunit
- neuroendocrine secretory protein 55
- stimulatory G-protein alpha subunit
- guanine nucleotide-binding protein G(s) subunit alpha isoforms
- G-alpha-8
- GNAS
- GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
- guanine nucleotide binding protein alpha s
- guanine nucleotide-binding protein G-s, alpha subunit
- guanine nucleotide binding protein, alpha stimulating, olfactory type
- guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like
- Galpha s
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