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Glutamate Dehydrogenase 1 Products

(Glutamate Dehydrogenase 1 (GLUD1))
This gene encodes glutamate dehydrogenase protein\; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.[provided by RefSeq, Sep 2009].

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Featured Glutamate Dehydrogenase 1 Categories

Glutamate Dehydrogenase 1 Antibodies

High quality antibodies with extensive validation data.

Glutamate Dehydrogenase 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Glutamate Dehydrogenase 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Glutamate Dehydrogenase 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (8)
Cat. No. ABIN7263621
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, IF
Validations
  • (7)
Cat. No. ABIN6141157
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (6)
Cat. No. ABIN7267411
Quantity 100 μL
Datasheet Datasheet

Recommended Glutamate Dehydrogenase 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962766
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956140
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956141
Quantity 96 tests
Datasheet Datasheet

Recommended Glutamate Dehydrogenase 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Cow
Source Cow
Validations
Cat. No. ABIN2129438
Quantity 1 kU
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN2129436
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7389884
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Glutamate Dehydrogenase 1 products

Geiszler, Ugun-Klusek, Lawler, Pardon, Yuchun, Bai, Daykin, Auer, Bedford: "Dynamic metabolic patterns tracking neurodegeneration and gliosis following 26S proteasome dysfunction in mouse forebrain neurons." in: Scientific reports, Vol. 8, Issue 1, pp. 4833, (2019) (PubMed).

Karri, Singh, Paripati, Marada, Krishnamoorthy, Guruprasad, Balasubramanian, Sepuri: "Adaptation of Mge1 to oxidative stress by local unfolding and altered Interaction with mitochondrial Hsp70 and Mxr2." in: Mitochondrion, (2018) (PubMed).

Rueda, Johnson, Giddabasappa, Swaroop, Brooks, Sigel, Chaney, Fox: "The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases." in: Molecular vision, Vol. 22, pp. 847-85, (2016) (PubMed).

Knudsen, Balaji, Freinkman, McCue, Witkiewicz: "Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential." in: Oncotarget, Vol. 7, Issue 48, pp. 78396-78411, (2016) (PubMed).

Li, Li, Li, Zhong, Ji, Yu, Zhang, Wen, Zhang, Goscinski, Nesland, Suo: "PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence." in: Oncotarget, Vol. 7, Issue 33, pp. 53837-53852, (2016) (PubMed).

Spanaki, Kotzamani, Plaitakis: "Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions." in: Neurochemical research, Vol. 42, Issue 1, pp. 92-107, (2016) (PubMed).

Spanaki, Kotzamani, Petraki, Drakos, Plaitakis: "Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues." in: Molecular and cellular endocrinology, Vol. 415, pp. 1-11, (2015) (PubMed).

Pougovkina, te Brinke, Ofman, van Cruchten, Kulik, Wanders, Houten, de Boer: "Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation." in: Human molecular genetics, Vol. 23, Issue 13, pp. 3513-22, (2015) (PubMed).

Jeong, Lee, Lee, Haigis: "SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma." in: The Journal of biological chemistry, Vol. 289, Issue 7, pp. 4135-44, (2014) (PubMed).

Yang, Ko, Hensley, Jiang, Wasti, Kim, Sudderth, Calvaruso, Lumata, Mitsche, Rutter, Merritt, DeBerardinis: "Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport." in: Molecular cell, Vol. 56, Issue 3, pp. 414-24, (2014) (PubMed).

Synonyms and alternative names related to Glutamate Dehydrogenase 1

glutamate dehydrogenase 1 (GLUD1), glutamate dehydrogenase 1 (GDH1), glutamate dehydrogenase 1 (glud1), glutamate dehydrogenase 1 S homeolog (glud1.S), glutamate dehydrogenase 1, mitochondrial (LOC693461), glutamate dehydrogenase 1b (glud1b), glutamate dehydrogenase 1 (Glud1), glutamate dehydrogenase (HACJB3_RS00320), glutamate dehydrogenase 1, mitochondrial (LOC100587725), non-compact myelin associated protein (NCMAP), glutamate dehydrogenase (gdh1), glutamate dehydrogenase 1a (glud1a), Ac2-281, AI118167, C2H1orf130, cb622, cb719, GDH, Gdh-X, gdh1, GDH 1, GDH1, Gdh1, GLUD, Glud, glud1, GLUD1, Gludeha, Gludl, GLUTAMATE DECARBOXYLASE 1, GLUTAMATE DEHYDROGENASE 1, glutamate dehydrogenase 1, legdh1, MRG-2, MRG7.13, MRG7_13, wu:fb16e02, wu:fb58f12, wu:fc33g09, wu:fc66a10, wu:fe37f03, wu:fj43f02, zgc:55630, zgc:77186, zgc:192851

Protein level used designations for Glutamate Dehydrogenase 1

  • GDH 1
  • glutamate dehydrogenase 1, mitochondrial
  • glutamate dehydrogenase 1
  • mitochondrial glutamate dehydrogenase 1
  • glutamate dehydrogenase (NAD(P)+)
  • memory-related gene 2 protein
  • glutamate dehydrogenase 1, mitochondrial-like
  • Legdh1
  • NADH-glutamate dehydrogenase
  • glutamate dehydrogenase
  • glutamate dehydrogenase 1a
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