GLI2 Products
(GLI Family Zinc Finger 2 (GLI2))
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This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008].
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Featured GLI2 Categories
GLI2 Antibodies
High quality antibodies with extensive validation data.
GLI2 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended GLI2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (23)
- (7)
- (2)
Cat. No.
ABIN2777474
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), IF, FACS
Validations
- (6)
Cat. No.
ABIN6243675
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, ELISA, IHC
Validations
- (1)
- (3)
Cat. No.
ABIN129624
Quantity
100 μg
Datasheet
Datasheet
Recommended GLI2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967001
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5594596
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN2870159
Quantity
96 tests
Datasheet
Datasheet
Latest Publications for our GLI2 products
: "Patched 1 Expression Correlates with Biochemical Relapse in High-Risk Prostate Cancer Patients." in: The American journal of pathology, Vol. 188, Issue 3, pp. 795-804, (2019) (PubMed).: "Direct repression of anoctamin 1 (ANO1) gene transcription by Gli proteins." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 5, pp. 6632-6642, (2019) (PubMed).
: "Differential effects of GLI2 and GLI3 in regulating cervical cancer malignancy in vitro and in vivo." in: Laboratory investigation; a journal of technical methods and pathology, (2018) (PubMed).
: "The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo." in: Oncotarget, Vol. 7, Issue 51, pp. 84286-84298, (2018) (PubMed).
: "Tissue microarray analysis indicates hedgehog signaling as a potential prognostic factor in intermediate-risk prostate cancer." in: BMC cancer, Vol. 17, Issue 1, pp. 634, (2018) (PubMed).
: "The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells." in: International journal of molecular sciences, Vol. 18, Issue 2, (2017) (PubMed).
: "Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis." in: The Journal of biological chemistry, Vol. 291, Issue 49, pp. 25749-25760, (2016) (PubMed).
: "Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy." in: PLoS ONE, Vol. 11, Issue 12, pp. e0167665, (2016) (PubMed).
: "Autophagy is related to the hedgehog signaling pathway in human gastric adenocarcinoma: prognostic significance of Beclin-1 and Gli2 expression in human gastric adenocarcinoma." in: Pathology, research and practice, Vol. 211, Issue 4, pp. 308-15, (2015) (PubMed).
: "Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen." in: Experimental neurology, Vol. 271, pp. 493-505, (2015) (PubMed).
Synonyms and alternative names related to GLI2
GLI family zinc finger 2 (GLI2), GLI family zinc finger 2 (Gli2), GLI-Kruppel family member GLI2 (Gli2), AW546128, GLI2/GLI4, GLI3, HPE9, THP1, THP2Protein level used designations for GLI2
- GLI-Kruppel family member GLI2
- glioma-associated oncogene family zinc finger 2
- oncogene GLI2
- tax helper protein 1
- tax helper protein 2
- tax-responsive element-2 holding protein
- tax-responsive element-25-bp sequence binding protein
- zinc finger protein GLI2
- Zn finger transcription factor
- zinc finger protein GLI3
- Tax helper protein
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