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GIT2 Products

(G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

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This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008].

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Featured GIT2 Categories

GIT2 Antibodies

High quality antibodies with extensive validation data.

GIT2 ELISA Kits

Reliable ELISA kits for a wide range of species.

GIT2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GIT2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p)
Validations
  • (5)
Cat. No. ABIN564230
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IP
Validations
  • (5)
Cat. No. ABIN564231
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, FACS
Validations
  • (4)
Cat. No. ABIN523246
Quantity 50 μg
Datasheet Datasheet

Recommended GIT2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN5648198
Quantity 96 tests
Datasheet Datasheet

Recommended GIT2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1355123
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1355125
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3080737
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our GIT2 products

Aslan, Baker, Loren, Haley, Itakura, Pang, Greenberg, David, Manser, Chernoff, McCarty: "The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation." in: American journal of physiology. Cell physiology, Vol. 305, Issue 5, pp. C519-28, (2013) (PubMed).

Martin, Chadwick, Yi, Park, Lu, Ni, Gadkaree, Farhang, Becker, Maudsley: "VENNTURE--a novel Venn diagram investigational tool for multiple pharmacological dataset analysis." in: PLoS ONE, Vol. 7, Issue 5, pp. e36911, (2012) (PubMed).

Chadwick, Martin, Chapter, Park, Wang, Daimon, Brenneman, Maudsley: "GIT2 acts as a potential keystone protein in functional hypothalamic networks associated with age-related phenotypic changes in rats." in: PLoS ONE, Vol. 7, Issue 5, pp. e36975, (2012) (PubMed).

Chadwick, Zhou, Park, Wang, Mitchell, Stone, Becker, Martin, Maudsley: "Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses." in: PLoS ONE, Vol. 5, Issue 12, pp. e14352, (2010) (PubMed).

Synonyms and alternative names related to GIT2

GIT ArfGAP 2 (GIT2), G protein-coupled receptor kinase interacting ArfGAP 2 (git2), G protein-coupled receptor kinase interacting ArfGAP 2a (git2a), G protein-coupled receptor kinase-interactor 2 (Git2), GIT ArfGAP 2 (Git2), G protein-coupled receptor kinase interacting ArfGAP 2 L homeolog (git2.L), G protein-coupled receptor kinase interacting ArfGAP 2b (git2b), 1500036H07Rik, 5830420E16Rik, 6430510B20Rik, 9630056M03Rik, B230104M05Rik, CAT-2, cat-2, CAT2, git2, mKIAA0148, si:dkey-234h16.4, xgit2, zgc:158416

Protein level used designations for GIT2

  • ARF GAP GIT2
  • ARF GTPase-activating protein GIT2
  • G protein-coupled receptor kinase-interactor 2
  • GRK-interacting protein 2
  • cool-associated, tyrosine phosphorylated protein 2
  • cool-interacting tyrosine-phosphorylated protein 2
  • G protein-coupled receptor kinase interactor 2
  • ARF GTPase activating protein 2
  • cool associated tyrosine phosphorylated-2
  • G protein-coupled receptor kinase interacting ArfGAP 2 L homeolog
  • G protein-coupled receptor kinase interacting ArfGAP 2
  • G protein-coupled receptor kinase interactor 2b
  • tyrosine-phosphorylated protein CAT-2
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