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GGA3 Products

(Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3))

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This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010].

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Featured GGA3 Categories

GGA3 Antibodies

High quality antibodies with extensive validation data.

GGA3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GGA3 Antibodies

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Reactivity Human
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Cat. No. ABIN2856386
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Cat. No. ABIN129660
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Cat. No. ABIN7143469
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Recommended GGA3 Proteins

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Reactivity Human
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Cat. No. ABIN1355043
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Source Tobacco (Nicotiana tabacum)
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Cat. No. ABIN3092757
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Latest Publications for our GGA3 products

Prag, Lee, Mattera, Arighi, Beach, Bonifacino, Hurley: "Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 7, pp. 2334-9, (2005) (PubMed).

Puertollano, Bonifacino: "Interactions of GGA3 with the ubiquitin sorting machinery." in: Nature cell biology, Vol. 6, Issue 3, pp. 244-51, (2004) (PubMed).

Bilodeau, Winistorfer, Allaman, Surendhran, Kearney, Robertson, Piper: "The GAT domains of clathrin-associated GGA proteins have two ubiquitin binding motifs." in: The Journal of biological chemistry, Vol. 279, Issue 52, pp. 54808-16, (2004) (PubMed).

Wakasugi, Waguri, Kametaka, Tomiyama, Kanamori, Shiba, Nakayama, Uchiyama: "Predominant expression of the short form of GGA3 in human cell lines and tissues." in: Biochemical and biophysical research communications, Vol. 306, Issue 3, pp. 687-92, (2003) (PubMed).

Misra, Puertollano, Kato, Bonifacino, Hurley: "Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains." in: Nature, Vol. 415, Issue 6874, pp. 933-7, (2002) (PubMed).

Puertollano, Aguilar, Gorshkova, Crouch, Bonifacino: "Sorting of mannose 6-phosphate receptors mediated by the GGAs." in: Science (New York, N.Y.), Vol. 292, Issue 5522, pp. 1712-6, (2001) (PubMed).

Hirst, Lui, Bright, Totty, Seaman, Robinson: "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome." in: The Journal of cell biology, Vol. 149, Issue 1, pp. 67-80, (2000) (PubMed).

Boman, Zhang, Zhu, Kahn: "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi." in: Molecular biology of the cell, Vol. 11, Issue 4, pp. 1241-55, (2000) (PubMed).

DellAngelica, Puertollano, Mullins, Aguilar, Vargas, Hartnell, Bonifacino: "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex." in: The Journal of cell biology, Vol. 149, Issue 1, pp. 81-94, (2000) (PubMed).

Synonyms and alternative names related to GGA3

golgi associated, gamma adaptin ear containing, ARF binding protein 3 (Gga3), golgi associated, gamma adaptin ear containing, ARF binding protein 3 (GGA3), C230037M19Rik, mKIAA0154

Protein level used designations for GGA3

  • ADP-ribosylation factor-binding protein GGA3
  • golgi-localized, gamma ear-containing, ARF-binding protein 3
  • Golgi-localized, gamma ear-containing, ARF-binding protein 3
  • golgi associated, gamma adaptin ear containing, ARF binding protein 3
  • ADP-ribosylation factor binding protein 3
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