GFI1 Products
(Growth Factor Independent 1 (GFI1))
Categories
This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].
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Featured GFI1 Categories
GFI1 Antibodies
High quality antibodies with extensive validation data.
GFI1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GFI1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (5)
Cat. No.
ABIN561035
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7245050
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN969174
Quantity
100 μL
Datasheet
Datasheet
Recommended GFI1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6222660
Quantity
96 tests
Datasheet
Datasheet
Recommended GFI1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355013
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3092738
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3134645
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our GFI1 products
: "Transcription factor induced conversion of human fibroblasts towards the hair cell lineage." in: PLoS ONE, Vol. 13, Issue 7, pp. e0200210, (2019) (PubMed).: "GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1." in: Nature communications, Vol. 9, Issue 1, pp. 1418, (2018) (PubMed).
: "Single-cell analysis of mixed-lineage states leading to a binary cell fate choice." in: Nature, Vol. 537, Issue 7622, pp. 698-702, (2017) (PubMed).
: "Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1." in: PLoS ONE, Vol. 11, Issue 7, pp. e0160344, (2017) (PubMed).
: "Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. ..." in: Nature, Vol. 511, Issue 7510, pp. 428-34, (2014) (PubMed).
: "Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells." in: The Journal of steroid biochemistry and molecular biology, Vol. 103, Issue 3-5, pp. 742-6, (2007) (PubMed).
: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, (2006) (PubMed).
Synonyms and alternative names related to GFI1
growth factor independent 1 (Gfi1), growth factor independent 1 transcriptional repressor (GFI1), growth factor independent 1 transcriptional repressor (Gfi1), AW495828, Gfi-1, GFI-1, GFI1, GFI1A, Pal-1, Pal1, SCN2, ZNF163Protein level used designations for GFI1
- growth factor independent protein 1
- zinc finger protein Gfi-1
- growth factor independent 1
- Growth factor independent-1
- growth factor independence-1
- zinc finger protein 163
- growth factor independence 1
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