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GEN1 Products

(Gen Endonuclease Homolog 1 (GEN1))
Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation.

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Featured GEN1 Categories

GEN1 Antibodies

High quality antibodies with extensive validation data.

GEN1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GEN1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB
Validations
  • (2)
Cat. No. ABIN653446
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6141058
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC
Validations
Cat. No. ABIN1715019
Quantity 100 μL
Datasheet Datasheet

Recommended GEN1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3092747
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3136234
Quantity 1 mg
Datasheet Datasheet
Reactivity Staphylococcus aureus
Source Yeast
Validations
  • (1)
Cat. No. ABIN5713720
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our GEN1 products

Malacaria, Franchitto, Pichierri: "SLX4 Prevents GEN1-Dependent DSBs During DNA Replication Arrest Under Pathological Conditions in Human Cells." in: Scientific reports, Vol. 7, pp. 44464, (2018) (PubMed).

Ip, Rass, Blanco, Flynn, Skehel, West: "Identification of Holliday junction resolvases from humans and yeast." in: Nature, Vol. 456, Issue 7220, pp. 357-61, (2008) (PubMed).

Synonyms and alternative names related to GEN1

GEN1, Holliday junction 5' flap endonuclease (GEN1), GEN1, Holliday junction 5' flap endonuclease (Gen1), GEN1 Holliday junction 5' flap endonuclease (Gen1), 5830483C08Rik, Gen, RGD1559792

Protein level used designations for GEN1

  • Gen homolog 1, endonuclease
  • flap endonuclease GEN homolog 1
  • Gen endonuclease homolog 1
  • Holliday junction resolvase
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