Geminin Products
(Geminin, DNA Replication Inhibitor (GMNN))
Categories
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011].
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Featured Geminin Categories
Geminin Antibodies
High quality antibodies with extensive validation data.
Geminin ELISA Kits
Reliable ELISA kits for a wide range of species.
Geminin Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Geminin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (7)
Cat. No.
ABIN565518
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN6141186
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (1)
- (2)
Cat. No.
ABIN1574066
Quantity
40 μg
Datasheet
Datasheet
Recommended Geminin ELISA Kits
Recommended Geminin Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355304
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1355302
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN667697
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Geminin products
: "GEMC1 is a critical regulator of multiciliated cell differentiation." in: The EMBO journal, Vol. 35, Issue 9, pp. 942-60, (2016) (PubMed).: "Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors." in: Development (Cambridge, England), Vol. 142, Issue 1, pp. 70-81, (2014) (PubMed).
: "Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis." in: Nature communications, Vol. 4, pp. 1885, (2013) (PubMed).
: "Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex." in: Nature cell biology, Vol. 15, Issue 7, pp. 797-806, (2013) (PubMed).
: "Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation." in: Molecular and cellular biology, Vol. 29, Issue 10, pp. 2609-21, (2009) (PubMed).
: "The regulation of embryonic patterning and DNA replication by geminin." in: Cellular and molecular life sciences : CMLS, Vol. 62, Issue 13, pp. 1425-33, (2005) (PubMed).
: "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions." in: Nature, Vol. 427, Issue 6976, pp. 749-53, (2004) (PubMed).
: "Increased expression of geminin stimulates the growth of mammary epithelial cells and is a frequent event in human tumors." in: Journal of cellular physiology, Vol. 202, Issue 1, pp. 215-22, (2004) (PubMed).
: "Identification of BRCA1-IRIS, a BRCA1 locus product." in: Nature cell biology, Vol. 6, Issue 10, pp. 954-67, (2004) (PubMed).
: "DNA replication licensing in somatic and germ cells." in: Journal of cell science, Vol. 117, Issue Pt 24, pp. 5875-86, (2004) (PubMed).
Synonyms and alternative names related to Geminin
geminin, DNA replication inhibitor (GMNN), CG3183 gene product from transcript CG3183-RA (geminin), geminin, DNA replication inhibitor (gmnn), geminin (LOC410093), GE24654 gene product from transcript GE24654-RA (Dyak\geminin), geminin (Gmnn), geminin, DNA replication inhibitor (Gmnn), anon-WO0257455.1, AW546347, CG3183, Dmel\\CG3183, Dm Geminin, Dm geminin, DyakGE24654, dyak_GLEANR_833, GB16871, GE24654, Gem, gem, Geminin, geminin, GMNN, l(2)k14019, LOC100049517, sb:cb254, v(2)k09107, zgc:66217Protein level used designations for Geminin
- CG3183-PA
- CG3183-PB
- geminin-PA
- geminin-PB
- geminin
- geminin protein
- geminin, DNA replication inhibitor
- DyakGE24654-PA
- Dyakgeminin-PA
- GE24654-PA
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