GEM Products
(GTP Binding Protein Overexpressed in Skeletal Muscle (GEM))
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This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011].
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Featured GEM Categories
GEM Antibodies
High quality antibodies with extensive validation data.
GEM ELISA Kits
Reliable ELISA kits for a wide range of species.
GEM Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GEM Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Bat, Cow, Dog, Guinea Pig, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Xenopus laevis
Application
WB, IHC, IHC (p)
Validations
- (3)
Cat. No.
ABIN203412
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Mouse, Rat
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN630220
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN2775304
Quantity
100 μL
Datasheet
Datasheet
Recommended GEM ELISA Kits
Recommended GEM Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354994
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3080640
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3120438
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our GEM products
: "Nerve injury induces a Gem-GTPase-dependent downregulation of P/Q-type Ca2+ channels contributing to neurite plasticity in dorsal root ganglion neurons." in: Pflügers Archiv : European journal of physiology, Vol. 467, Issue 2, pp. 351-66, (2015) (PubMed).: "High expression of GEM and EDNRA is associated with metastasis and poor outcome in patients with advanced bladder cancer." in: BMC cancer, Vol. 14, pp. 638, (2014) (PubMed).
: "A systemic network for Chlamydia pneumoniae entry into human cells." in: Journal of bacteriology, Vol. 192, Issue 11, pp. 2809-15, (2010) (PubMed).
: "Equine herpesvirus 1 enters cells by two different pathways, and infection requires the activation of the cellular kinase ROCK1." in: Journal of virology, Vol. 81, Issue 20, pp. 10879-89, (2007) (PubMed).
Synonyms and alternative names related to GEM
GTP binding protein overexpressed in skeletal muscle (GEM), GTP binding protein overexpressed in skeletal muscle (gem), GTP binding protein overexpressed in skeletal muscle (Gem), geminin, DNA replication inhibitor (GMNN), GTP binding protein (gene overexpressed in skeletal muscle) (Gem), AV020497, DKFZp470D0612, GEM, Gem, KIR, kir, LOC100221129, xgem, zgc:153003Protein level used designations for GEM
- GTP-binding mitogen-induced T-cell protein
- GTP-binding protein GEM
- GTP-binding protein overexpressed in skeletal muscle
- RAS-like protein KIR
- kinase-inducible Ras-like protein
- GTP binding protein overexpressed in skeletal muscle
- Gem GTPase
- GTP binding protein gene overexpressed in skeletal muscle
- GTP binding protein (gene overexpressed in skeletal muscle)
- geminin
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