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GCN2 Products

(Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4))

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EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1\; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 [PubMed 10504407]).[supplied by OMIM, Mar 2008].

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Featured GCN2 Categories

GCN2 Antibodies

High quality antibodies with extensive validation data.

GCN2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GCN2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, WB, IF
Validations
  • (6)
Cat. No. ABIN6140031
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, FACS
Validations
  • (1)
  • (4)
Cat. No. ABIN684943
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (4)
Cat. No. ABIN684958
Quantity 100 μL
Datasheet Datasheet

Recommended GCN2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352506
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352508
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5508907
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our GCN2 products

Lehman, Ryeom, Koumenis: "Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma." in: Scientific reports, Vol. 5, pp. 11781, (2015) (PubMed).

Fougeray, Mami, Bertho, Beaune, Thervet, Pallet: "Tryptophan depletion and the kinase GCN2 mediate IFN-?-induced autophagy." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 6, pp. 2954-64, (2012) (PubMed).

Lu, László, Miao, Chen, Wu: "The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2." in: The Journal of biological chemistry, Vol. 284, Issue 36, pp. 24281-8, (2009) (PubMed).

Rahmani, Davis, Crabtree, Habibi, Nguyen, Dent, Grant: "The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress." in: Molecular and cellular biology, Vol. 27, Issue 15, pp. 5499-513, (2007) (PubMed).

Cantrell: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).

Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).

Jhiang: "The RET proto-oncogene in human cancers." in: Oncogene, Vol. 19, Issue 49, pp. 5590-7, (2000) (PubMed).

Synonyms and alternative names related to GCN2

eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4), eukaryotic translation initiation factor 2-alpha kinase 4 (LOC579979), eIF-2-alpha kinase GCN2 (LOC100187226), eukaryotic translation initiation factor 2 alpha kinase 4 (eif2ak4), eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4), 2610011M03, EIF2AK4, GCN2, Gcn2-like, MGCN2

Protein level used designations for GCN2

  • eukaryotic translation initiation factor 2 alpha kinase 4
  • eukaryotic translation initiation factor 2-alpha kinase 4-like
  • GCN2 protein
  • GCN2 eIF2alpha kinase
  • GCN2-like protein
  • eukaryotic translation initiation factor 2-alpha kinase 4
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