GCLM Products
(Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))
Categories
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008].
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Featured GCLM Categories
GCLM Antibodies
High quality antibodies with extensive validation data.
GCLM ELISA Kits
Reliable ELISA kits for a wide range of species.
GCLM Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GCLM Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, FACS, IHC (p)
Validations
- (1)
- (7)
Cat. No.
ABIN653046
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (11)
Cat. No.
ABIN7433051
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, IF
Validations
- (4)
Cat. No.
ABIN7154002
Quantity
100 μg
Datasheet
Datasheet
Recommended GCLM ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967070
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967069
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956169
Quantity
96 tests
Datasheet
Datasheet
Recommended GCLM Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354926
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2129377
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7411648
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our GCLM products
: "A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity." in: Cell reports, Vol. 26, Issue 6, pp. 1544-1556.e8, (2019) (PubMed).: "Oregano Essential Oil Induces SOD1 and GSH Expression through Nrf2 Activation and Alleviates Hydrogen Peroxide-Induced Oxidative Damage in IPEC-J2 Cells." in: Oxidative medicine and cellular longevity, Vol. 2016, pp. 5987183, (2017) (PubMed).
: "Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 102, pp. 93-101, (2017) (PubMed).
: "Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 33, pp. E4600-9, (2015) (PubMed).
: "Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice." in: Free radical biology & medicine, Vol. 68, pp. 148-58, (2014) (PubMed).
: "The protective role of resveratrol in the sodium arsenite-induced oxidative damage via modulation of intracellular GSH homeostasis." in: Biological trace element research, Vol. 155, Issue 1, pp. 119-31, (2014) (PubMed).
: "Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis." in: The Journal of biological chemistry, Vol. 287, Issue 43, pp. 36341-55, (2012) (PubMed).
: "Molecular and functional characterizations of gastrula organizer cells derived from human embryonic stem cells." in: Stem cells (Dayton, Ohio), Vol. 29, Issue 4, pp. 600-8, (2011) (PubMed).
: "Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway." in: Toxicology and applied pharmacology, Vol. 255, Issue 2, pp. 176-83, (2011) (PubMed).
: "Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 38, Issue 12, pp. 2293-301, (2010) (PubMed).
Synonyms and alternative names related to GCLM
glutamate-cysteine ligase regulatory subunit (PTRG_09814), glutamate cysteine ligase, modifier subunit (Gclm), glutamate-cysteine ligase modifier subunit (GCLM), glutamate-cysteine ligase, modifier subunit (gclm), glutamate-cysteine ligase, modifier subunit L homeolog (gclm.L), glutamate-cysteine ligase, modifier subunit (Gclm), glutamate-cysteine ligase modifier subunit (Gclm), AI649393, Gcmc, Glclr, GLCLR, id:ibd3182, wu:fi24c07, zgc:55903Protein level used designations for GCLM
- glutamate-cysteine ligase regulatory subunit
- GCS light chain
- gamma-ECS regulatory subunit
- gamma-glutamylcysteine synthetase regulatory subunit
- glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory
- glutamate--cysteine ligase regulatory subunit
- glutamate-cysteine ligase modifier subunit
- GSC light chain
- glutamate--cysteine ligase modifier subunit
- glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)
- glutamate-cysteine ligase modifier subunit delta2 alternative splicing
- glutamate-cysteine ligase regulatory protein
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