GCLC Products
(Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
Categories
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010].
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Featured GCLC Categories
GCLC Antibodies
High quality antibodies with extensive validation data.
GCLC ELISA Kits
Reliable ELISA kits for a wide range of species.
GCLC Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GCLC Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (6)
- (7)
Cat. No.
ABIN561050
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, FACS, IHC (p)
Validations
- (1)
- (4)
Cat. No.
ABIN655884
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (1)
- (5)
Cat. No.
ABIN2774078
Quantity
100 μL
Datasheet
Datasheet
Recommended GCLC ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6956167
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967068
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956168
Quantity
96 tests
Datasheet
Datasheet
Recommended GCLC Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123113
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354922
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354924
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our GCLC products
: "Overexpression of Brg1 Alleviates Hepatic Ischemia/Reperfusion-Induced Acute Lung Injury through Antioxidative Stress Effects." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 8787392, (2018) (PubMed).: "Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks." in: Biological trace element research, Vol. 186, Issue 1, pp. 226-237, (2018) (PubMed).
: "Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice." in: PLoS ONE, Vol. 13, Issue 5, pp. e0198139, (2018) (PubMed).
: "Oregano Essential Oil Induces SOD1 and GSH Expression through Nrf2 Activation and Alleviates Hydrogen Peroxide-Induced Oxidative Damage in IPEC-J2 Cells." in: Oxidative medicine and cellular longevity, Vol. 2016, pp. 5987183, (2017) (PubMed).
: "Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 102, pp. 93-101, (2017) (PubMed).
: "Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary fibrosis in rat by activating Nrf2 signaling." in: International journal of clinical and experimental pathology, Vol. 8, Issue 7, pp. 7752-61, (2016) (PubMed).
: "Electroacupuncture alleviates cerebral ischemia and reperfusion injury via modulation of the ERK1/2 signaling pathway." in: Neural regeneration research, Vol. 11, Issue 7, pp. 1090-8, (2016) (PubMed).
: "Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake." in: The Journal of biological chemistry, Vol. 290, Issue 36, pp. 21788-99, (2015) (PubMed).
: "Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus." in: PLoS ONE, Vol. 9, Issue 4, pp. e94460, (2014) (PubMed).
: "Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress." in: Neoplasia (New York, N.Y.), Vol. 16, Issue 9, pp. 710-22, (2014) (PubMed).
Synonyms and alternative names related to GCLC
glutamate-cysteine ligase catalytic subunit (GCLC), glutamate-cysteine ligase, catalytic subunit (gclc), Glutamate-cysteine ligase catalytic subunit (Gclc), gamma glutamylcysteine synthetase (LbGCS), gamma glutamylcysteine synthetase (gcsA), glutamate-cysteine ligase, catalytic subunit L homeolog (gclc.L), glutamate-cysteine ligase, catalytic subunit S homeolog (gclc.S), gamma-glutamylcysteine synthetase (GSH1), glutamate-cysteine ligase, catalytic subunit (Gclc), glutamate-cysteine ligase catalytic subunit (Gclc), 2259, cb1049, CG2259, D9Wsu168e, DDBDRAFT_0186120, DDBDRAFT_0231403, DDB_0186120, DDB_0231403, Dmel\\CG2259, DmGCLC, DmGCS, DmGCSh, fe36e11, GCL, GCLC, gclc, GCLc, Gcs, GCS, GCSh, Gcsh, Ggcs-hs, GLCL, GLCL-H, GLCLC, Glclc, MGC146287, wu:fe36e11Protein level used designations for GCLC
- glutamate--cysteine ligase catalytic subunit
- glutamate-cysteine ligase, catalytic subunit
- CG2259-PA
- CG2259-PB
- Gclc-PA
- Gclc-PB
- gamma-Glutamylcysteine synthetase
- gamma-Glutamylcysteine synthetase catalytic subunit
- gamma-glutamylcysteine ligase
- glutamate cysteine ligase
- glutamate-cysteine ligase
- gamma glutamylcysteine synthetase
- gamma-ECS
- glutamate--cysteine ligase, chloroplastic
- GCS heavy chain
- gamma-glutamylcysteine synthetase
- gamma GCS-HS
- gamma-glutamylcysteine synthetase heavy subunit
- Glutamylcysteine gamma synthetase light chain
- glutamate-cysteine ligase catalytic subunit
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