GCK Products
(Glucokinase (Hexokinase 4) (GCK))
Categories
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009].
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Featured GCK Categories
GCK Antibodies
High quality antibodies with extensive validation data.
GCK ELISA Kits
Reliable ELISA kits for a wide range of species.
GCK Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GCK Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (6)
Cat. No.
ABIN515989
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
- (2)
- (3)
Cat. No.
ABIN969172
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7429088
Quantity
100 μL
Datasheet
Datasheet
Recommended GCK ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6956118
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956116
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967028
Quantity
96 tests
Datasheet
Datasheet
Recommended GCK Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354918
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354920
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123102
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our GCK products
: "Hypoglycemic effects of wheat bran alkyresorcinols in high-fat/high-sucrose diet and low-dose streptozotocin-induced type 2 diabetic male mice and protection of pancreatic β cells." in: Food & function, Vol. 10, Issue 6, pp. 3282-3290, (2019) (PubMed).: "Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt." in: Frontiers in pharmacology, Vol. 10, pp. 261, (2019) (PubMed).
: "Improvement of Lipid and Glucose Metabolism by Capsiate in Palmitic Acid-Treated HepG2 Cells via Activation of the AMPK/SIRT1 Signaling Pathway." in: Journal of agricultural and food chemistry, Vol. 66, Issue 26, pp. 6772-6781, (2018) (PubMed).
: "Vitamin C and E chronic supplementation differentially affect hepatic insulin signaling in rats." in: Life sciences, Vol. 194, pp. 196-204, (2018) (PubMed).
: "Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus." in: Journal of diabetes research, Vol. 2017, pp. 5812607, (2017) (PubMed).
: "Anti-diabetes effect of chronic intermittent hypobaric hypoxia through improving liver insulin resistance in diabetic rats." in: Life sciences, Vol. 150, pp. 1-7, (2016) (PubMed).
: "MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPARγ." in: RNA (New York, N.Y.), Vol. 21, Issue 3, pp. 385-400, (2015) (PubMed).
: "The Possible Mechanisms of the Impaired Insulin Secretion in Hypothyroid Rats." in: PLoS ONE, Vol. 10, Issue 7, pp. e0131198, (2015) (PubMed).
: "Role of glucokinase in the subcellular localization of glucokinase regulatory protein." in: International journal of molecular sciences, Vol. 16, Issue 4, pp. 7377-93, (2015) (PubMed).
: "Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene." in: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 12, pp. 1983-9, (2009) (PubMed).
Synonyms and alternative names related to GCK
glucokinase (GCK), glucokinase (Gck), glucokinase (glcK), glucokinase (Bphyt_1025), glucokinase (Halhy_6548), glucokinase (gk), glucokinase (hexokinase 4) L homeolog (gck.L), glucokinase (hexokinase 4) (gck), BA4487, FGQTL3, GCK, gck-A, GK, Gk, GLK, glk, Gls006, glucokinase, GLUKA, HHF3, hhf3, HK4, hk4, HKIV, hkiv, HXKP, hxkp, LGLK, MODY2, mody2, RNGK2Protein level used designations for GCK
- ATP:D-hexose 6-phosphotransferase
- HK IV
- glucokinase
- hexokinase D, pancreatic isozyme
- hexokinase type IV
- hexokinase-4
- hexokinase-D
- hexokinase 4
- glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
- HK4
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