GCH1 Products
(GTP Cyclohydrolase 1 (GCH1))
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This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008].
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Featured GCH1 Categories
GCH1 Antibodies
High quality antibodies with extensive validation data.
GCH1 ELISA Kits
Reliable ELISA kits for a wide range of species.
GCH1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GCH1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IP
Validations
- (11)
- (6)
Cat. No.
ABIN561018
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN7267525
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (3)
Cat. No.
ABIN302137
Quantity
100 μg
Datasheet
Datasheet
Recommended GCH1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1135670
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1135671
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1135672
Quantity
96 tests
Datasheet
Datasheet
Recommended GCH1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1354910
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354912
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7422661
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our GCH1 products
: "Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats." in: Vascular pharmacology, Vol. 71, pp. 181-91, (2015) (PubMed).: "Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²?-induced apoptosis." in: Free radical biology & medicine, Vol. 74, pp. 188-99, (2014) (PubMed).
: "Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II." in: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27540-50, (2014) (PubMed).
: "Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages." in: International journal of cancer. Journal international du cancer, Vol. 132, Issue 3, pp. 591-604, (2012) (PubMed).
: "Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency." in: Journal of vascular research, Vol. 48, Issue 4, pp. 275-84, (2011) (PubMed).
: "Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 3, pp. L334-45, (2011) (PubMed).
: "Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy." in: Diabetes, Vol. 60, Issue 10, pp. 2608-16, (2011) (PubMed).
: "Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress." in: Basic research in cardiology, Vol. 106, Issue 6, pp. 1147-58, (2011) (PubMed).
: "Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus." in: Atherosclerosis, Vol. 198, Issue 1, pp. 65-76, (2008) (PubMed).
: "Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion." in: American journal of nephrology, Vol. 28, Issue 4, pp. 692-700, (2008) (PubMed).
Synonyms and alternative names related to GCH1
GTP cyclohydrolase 1 (GCH1), GTP cyclohydrolase 1 (Gch1), GTP cyclohydrolase 1 (gch1), GTP cyclohydrolase 1 (Weevi_1190), GTP cyclohydrolase 1 (Halhy_0838), GTP cyclohydrolase 1 (Sinme_1220), GTP cyclohydrolase 1 (Sphch_1077), GTP cyclohydrolase 1-like (LOC100136794), DYT5, DYT5a, DYT14, GCH, Gch, gch1a, GTP-CH, GTP-CH-1, GTPCH, GTPCH1, HPABH4B, MGC89622, wu:fc16b10, zgc:195269Protein level used designations for GCH1
- GTP cyclohydrolase I
- GTP-CH-I
- dystonia 14
- guanosine 5'-triphosphate cyclohydrolase I
- GTP cyclohydrolase 1 (dopa-responsive dystonia)
- GTP cyclohydrolase 1
- GTP cyclohydrolase I (form A; N-terminus)
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