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GCAP1 Products

(Guanylate Cyclase Activator 1A (Retina) (GUCA1A))

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This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3)\; a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations\; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq, Feb 2009].

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Featured GCAP1 Categories

GCAP1 Antibodies

High quality antibodies with extensive validation data.

GCAP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GCAP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, RNAi
Validations
  • (3)
Cat. No. ABIN561186
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7247552
Quantity 200 μL
Datasheet Datasheet
Reactivity Dog, Hamster, Horse, Human, Monkey, Mouse, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN6743766
Quantity 100 μL
Datasheet Datasheet

Recommended GCAP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6951132
Quantity 96 tests
Datasheet Datasheet

Recommended GCAP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1306202
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1306200
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2721755
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our GCAP1 products

Pennesi, Howes, Baehr, Wu: "Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 11, pp. 6783-8, (2003) (PubMed).

Synonyms and alternative names related to GCAP1

guanylate cyclase activator 1A (GUCA1A), guanylate cyclase activator 1A (Guca1a), guanylate cyclase activator 1A L homeolog (guca1a.L), guanylate cyclase activator 1A (retina) (guca1a), guanylate cyclase activator 1a (retina) (Guca1a), guanylate cyclase activator 1A (guca1a), C6orf131, COD3, CORD14, dJ139D8.6, GC-A, GCAP, GCAP1, Gcap1, gcap1, GUCA, GUCA1, Guca1, GUCA1A, guca1a, MGC84170, MGC146317, mGCAP1

Protein level used designations for GCAP1

  • GCAP 1
  • cone dystrophy 3
  • guanylate cyclase-activating protein, photoreceptor 1
  • guanylin 1, retina
  • guanylyl cyclase-activating protein 1
  • guanylate cyclase activator 1A (retina)
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