GCAP1 Products
(Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
Categories
This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3)\; a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations\; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq, Feb 2009].
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Featured GCAP1 Categories
GCAP1 Antibodies
High quality antibodies with extensive validation data.
GCAP1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GCAP1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, RNAi
Validations
- (3)
Cat. No.
ABIN561186
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7247552
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Dog, Hamster, Horse, Human, Monkey, Mouse, Rat
Application
WB
Validations
- (1)
Cat. No.
ABIN6743766
Quantity
100 μL
Datasheet
Datasheet
Recommended GCAP1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951132
Quantity
96 tests
Datasheet
Datasheet
Recommended GCAP1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306202
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306200
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2721755
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our GCAP1 products
: "Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 11, pp. 6783-8, (2003) (PubMed).Synonyms and alternative names related to GCAP1
guanylate cyclase activator 1A (GUCA1A), guanylate cyclase activator 1A (Guca1a), guanylate cyclase activator 1A L homeolog (guca1a.L), guanylate cyclase activator 1A (retina) (guca1a), guanylate cyclase activator 1a (retina) (Guca1a), guanylate cyclase activator 1A (guca1a), C6orf131, COD3, CORD14, dJ139D8.6, GC-A, GCAP, GCAP1, Gcap1, gcap1, GUCA, GUCA1, Guca1, GUCA1A, guca1a, MGC84170, MGC146317, mGCAP1Protein level used designations for GCAP1
- GCAP 1
- cone dystrophy 3
- guanylate cyclase-activating protein, photoreceptor 1
- guanylin 1, retina
- guanylyl cyclase-activating protein 1
- guanylate cyclase activator 1A (retina)
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