GALE Products
(UDP-Galactose-4-Epimerase (GALE))
Categories
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
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Featured GALE Categories
GALE Antibodies
High quality antibodies with extensive validation data.
GALE ELISA Kits
Reliable ELISA kits for a wide range of species.
GALE Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GALE Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Dog, Human, Monkey, Rat
Application
WB, IHC, IHC (p)
Validations
- (11)
Cat. No.
ABIN1498366
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (6)
Cat. No.
ABIN5693266
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7174611
Quantity
100 μg
Datasheet
Datasheet
Recommended GALE ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1165298
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1165299
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1165300
Quantity
96 tests
Datasheet
Datasheet
Recommended GALE Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125646
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354710
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2129337
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our GALE products
: "Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate ..." in: The Journal of biological chemistry, Vol. 287, Issue 34, pp. 28882-97, (2012) (PubMed).Synonyms and alternative names related to GALE
UDP-galactose-4-epimerase (GALE), UDP-galactose-4-epimerase (gale), NAD(P)-binding Rossmann-fold superfamily protein (RHD1), UDP-galactose-4-epimerase (ECs0787), UDP-galactose-4-epimerase (galE), UDP-galactose 4-epimerase GalE (galE), UDP-glucose 4-epimerase (galE1), UDP-glucose 4-epimerase (galE2), UDP-glucose 4-epimerase GalE (galE), UDP-glucose 4-epimerase (STY0809), UDP-glucose 4-epimerase (galE), UDP-glucose/UDP-N-acetylglucosamine 4-epimerase (galE), UDP-glucose 4-epimerase (galE-2), UDP-galactose-4-epimerase (SG0897), UDP-galactose-4-epimerase (galD), UDP-galactose-4-epimerase (Ent638_1250), galactose-4-epimerase, UDP (Gale), UDP-galactose-4-epimerase L homeolog (gale.L), UDP-galactose-4-epimerase (Gale), 1n569, 2310002A12Rik, AI323962, BA5505, BA5700, ECK0748, F15H21.11, F15H21_11, galD, GALE, galE, im:7147391, JW0742, REB1, ROOT EPIDERMAL BULGER1, ROOT HAIR DEFECTIVE 1, SDR1E1, SMU.888, UDP-GLUCOSE 4-EPIMERASE, UGE4, VFA0352, wu:fb05f01, xgale, zgc:136578Protein level used designations for GALE
- UDP-galactose-4-epimerase
- UDP-glucose 4-epimerase
- fb05f01
- UDP-galactose 4-epimerase
- galactowaldenase
- UDP-glucose (37.7 kD) (1N569)
- UDP galactose-4'-epimerase
- galactose-4-epimerase, UDP-
- short chain dehydrogenase/reductase family 1E, member 1
- galactose-4-epimerase, UDP
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