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GAD65 Products

(Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2))

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This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008].

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Featured GAD65 Categories

GAD65 Antibodies

High quality antibodies with extensive validation data.

GAD65 ELISA Kits

Reliable ELISA kits for a wide range of species.

GAD65 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GAD65 Antibodies

Product
Reactivity
Application
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Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
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Cat. No. ABIN7433339
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
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Cat. No. ABIN949999
Quantity 100 μL
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Reactivity Rat
Application WB, IHC, IP, ICC
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Cat. No. ABIN7437707
Quantity 100 μL
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Recommended GAD65 ELISA Kits

Product
Reactivity
Analytical Method
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Cat. No.
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Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
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Cat. No. ABIN6967053
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
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  • (1)
Cat. No. ABIN6967052
Quantity 96 tests
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Reactivity Human
Analytical Method Quantitative Sandwich ELISA
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Cat. No. ABIN6956137
Quantity 96 tests
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Recommended GAD65 Proteins

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Source Wheat germ
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Cat. No. ABIN1354671
Quantity 10 μg
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Reactivity Mouse
Source Baculovirus infected Insect Cells
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Cat. No. ABIN7320200
Quantity 20 μg
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Reactivity Mouse
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Cat. No. ABIN7320201
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Latest Publications for our GAD65 products

Cai, Yang, Hu, Chen, Niu, Yuan, Liu, Xiong, Arikkath, Buch: "Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy." in: The Journal of cell biology, Vol. 215, Issue 2, pp. 245-258, (2016) (PubMed).

Du, Chazalon, Bestaven, Leste-Lasserre, Baufreton, Cazalets, Cho, Garret: "Early GABAergic transmission defects in the external globus pallidus and rest/activity rhythm alteration in a mouse model of Huntington's disease." in: Neuroscience, Vol. 329, pp. 363-79, (2016) (PubMed).

Jewett, Christian, Bacos, Lee, Zhu, Tsai: "Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling." in: Molecular brain, Vol. 9, pp. 32, (2016) (PubMed).

Gresa-Arribas, Ariño, Martínez-Hernández, Petit-Pedrol, Sabater, Saiz, Dalmau, Graus: "Antibodies to inhibitory synaptic proteins in neurological syndromes associated with glutamic acid decarboxylase autoimmunity." in: PLoS ONE, Vol. 10, Issue 3, pp. e0121364, (2015) (PubMed).

Kaczor, Rakus, Mozrzymas: "Neuron-astrocyte interaction enhance GABAergic synaptic transmission in a manner dependent on key metabolic enzymes." in: Frontiers in cellular neuroscience, Vol. 9, pp. 120, (2015) (PubMed).

Pan, Marrs, Ryan: "Vesicular glutamate transporter 1 orchestrates recruitment of other synaptic vesicle cargo proteins during synaptic vesicle recycling." in: The Journal of biological chemistry, Vol. 290, Issue 37, pp. 22593-601, (2015) (PubMed).

Tian, Ma, Shi, Lou, Liu, Li: "Acrylamide neurotoxicity on the cerebrum of weaning rats." in: Neural regeneration research, Vol. 10, Issue 6, pp. 938-43, (2015) (PubMed).

Liu, Bickford, Held, Nyitrai, Südhof, Kaeser: "The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 37, pp. 12289-303, (2014) (PubMed).

Coley, Ruffin, Moss, Hopfer, Boron: "Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons." in: Neuroscience, Vol. 246, pp. 451-67, (2013) (PubMed).

Grigoryan, Segal: "Prenatal stress affects network properties of rat hippocampal neurons." in: Biological psychiatry, Vol. 73, Issue 11, pp. 1095-102, (2013) (PubMed).

Synonyms and alternative names related to GAD65

glutamate decarboxylase 2 (GAD2), glutamate decarboxylase 2 (PTRG_06148), glutamate decarboxylase 2 (LOC9324534), glutamate decarboxylase 2 (Gad2), glutamate decarboxylase 1 (GAD1), glutamate decarboxylase 2 (gad2), glutamic acid decarboxylase 2 (Gad2), 6330404F12Rik, F12P19.12, F12P19_12, GAD(65), Gad-2, GAD65, gad65, GLUTAMATE DECARBOXYLASE 2, glutamate decarboxylase 2, zgc:112198

Protein level used designations for GAD65

  • glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
  • glutamate decarboxylase 2
  • glutamic acid decarboxylase
  • 65 kDa glutamic acid decarboxylase
  • GAD-65
  • Glutamate decarboxylase 2 (islet)
  • glutamate decarboxylase 65 kDa isoform
  • glutamic acid decarboxylase 2
  • glutamic acid decarboxylase 65
  • Glutamate decarboxylase-2 (pancreas)
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