GAD65 Products
(Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2))
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This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008].
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Featured GAD65 Categories
GAD65 Antibodies
High quality antibodies with extensive validation data.
GAD65 ELISA Kits
Reliable ELISA kits for a wide range of species.
GAD65 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GAD65 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7433339
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (6)
Cat. No.
ABIN949999
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7437707
Quantity
100 μL
Datasheet
Datasheet
Recommended GAD65 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967053
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967052
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956137
Quantity
96 tests
Datasheet
Datasheet
Recommended GAD65 Proteins
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Reactivity
Source
Validations
Cat. No.
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Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (2)
- (1)
Cat. No.
ABIN1354671
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN7320200
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN7320201
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our GAD65 products
: "Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy." in: The Journal of cell biology, Vol. 215, Issue 2, pp. 245-258, (2016) (PubMed).: "Early GABAergic transmission defects in the external globus pallidus and rest/activity rhythm alteration in a mouse model of Huntington's disease." in: Neuroscience, Vol. 329, pp. 363-79, (2016) (PubMed).
: "Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling." in: Molecular brain, Vol. 9, pp. 32, (2016) (PubMed).
: "Antibodies to inhibitory synaptic proteins in neurological syndromes associated with glutamic acid decarboxylase autoimmunity." in: PLoS ONE, Vol. 10, Issue 3, pp. e0121364, (2015) (PubMed).
: "Neuron-astrocyte interaction enhance GABAergic synaptic transmission in a manner dependent on key metabolic enzymes." in: Frontiers in cellular neuroscience, Vol. 9, pp. 120, (2015) (PubMed).
: "Vesicular glutamate transporter 1 orchestrates recruitment of other synaptic vesicle cargo proteins during synaptic vesicle recycling." in: The Journal of biological chemistry, Vol. 290, Issue 37, pp. 22593-601, (2015) (PubMed).
: "Acrylamide neurotoxicity on the cerebrum of weaning rats." in: Neural regeneration research, Vol. 10, Issue 6, pp. 938-43, (2015) (PubMed).
: "The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 37, pp. 12289-303, (2014) (PubMed).
: "Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons." in: Neuroscience, Vol. 246, pp. 451-67, (2013) (PubMed).
: "Prenatal stress affects network properties of rat hippocampal neurons." in: Biological psychiatry, Vol. 73, Issue 11, pp. 1095-102, (2013) (PubMed).
Synonyms and alternative names related to GAD65
glutamate decarboxylase 2 (GAD2), glutamate decarboxylase 2 (PTRG_06148), glutamate decarboxylase 2 (LOC9324534), glutamate decarboxylase 2 (Gad2), glutamate decarboxylase 1 (GAD1), glutamate decarboxylase 2 (gad2), glutamic acid decarboxylase 2 (Gad2), 6330404F12Rik, F12P19.12, F12P19_12, GAD(65), Gad-2, GAD65, gad65, GLUTAMATE DECARBOXYLASE 2, glutamate decarboxylase 2, zgc:112198Protein level used designations for GAD65
- glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
- glutamate decarboxylase 2
- glutamic acid decarboxylase
- 65 kDa glutamic acid decarboxylase
- GAD-65
- Glutamate decarboxylase 2 (islet)
- glutamate decarboxylase 65 kDa isoform
- glutamic acid decarboxylase 2
- glutamic acid decarboxylase 65
- Glutamate decarboxylase-2 (pancreas)
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