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GAD Products

(Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1))

Categories

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008].

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Featured GAD Categories

GAD Antibodies

High quality antibodies with extensive validation data.

GAD ELISA Kits

Reliable ELISA kits for a wide range of species.

GAD Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GAD Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, ICC, IHC (p), IF, IHC (fro), IHC (ff), IHC (wm)
Validations
  • (7)
Cat. No. ABIN2855214
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (7)
Cat. No. ABIN3017019
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7437155
Quantity 100 μL
Datasheet Datasheet

Recommended GAD ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (5)
Cat. No. ABIN6574313
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967051
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967050
Quantity 96 tests
Datasheet Datasheet

Recommended GAD Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354667
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505296
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7401104
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our GAD products

Magri, Giacopuzzi, La Via, Bonini, Ravasio, Elhussiny, Orizio, Gangemi, Valsecchi, Bresciani, Barbon, Vita, Gennarelli: "A novel homozygous mutation in GAD1 gene described in a schizophrenic patient impairs activity and dimerization of GAD67 enzyme." in: Scientific reports, Vol. 8, Issue 1, pp. 15470, (2018) (PubMed).

Yang, Wang, He, Ding, Sun, Hua, Xi: "Dietary Restriction Affects Neuronal Response Property and GABA Synthesis in the Primary Visual Cortex." in: PLoS ONE, Vol. 11, Issue 2, pp. e0149004, (2016) (PubMed).

Gresa-Arribas, Ariño, Martínez-Hernández, Petit-Pedrol, Sabater, Saiz, Dalmau, Graus: "Antibodies to inhibitory synaptic proteins in neurological syndromes associated with glutamic acid decarboxylase autoimmunity." in: PLoS ONE, Vol. 10, Issue 3, pp. e0121364, (2015) (PubMed).

Beske, Scheeler, Adler, McNutt: "Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing." in: Frontiers in cellular neuroscience, Vol. 9, pp. 159, (2015) (PubMed).

Agca, Houen, Trier: "Characterization of continuous B-cell epitopes in the N-terminus of glutamate decarboxylase67 using monoclonal antibodies." in: Journal of peptide science : an official publication of the European Peptide Society, Vol. 20, Issue 12, pp. 928-34, (2014) (PubMed).

Mouton-Liger, Sahún, Collin, Lopes Pereira, Masini, Thomas, Paly, Luilier, Même, Jouhault, Bennaï, Beloeil, Bizot, Hérault, Dierssen, Créau: "Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome." in: Neurobiology of disease, Vol. 63, pp. 92-106, (2014) (PubMed).

Mikhaylova, Karpova, Bär, Bethge, YuanXiang, Chen, Zuschratter, Behnisch, Kreutz: "Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger Jacob in the rat brain." in: Brain structure & function, Vol. 219, Issue 3, pp. 843-60, (2014) (PubMed).

Maekawa, Kobayashi, Odagaki, Makino, Kumanogoh, Nakamura, Morita, Hayashi: "Interaction of NAP-22 with brain glutamic acid decarboxylase (GAD)." in: Neuroscience letters, Vol. 537, pp. 50-4, (2013) (PubMed).

Valladolid-Acebes, Merino, Principato, Fole, Barbas, Lorenzo, García, Del Olmo, Ruiz-Gayo, Cano: "High-fat diets induce changes in hippocampal glutamate metabolism and neurotransmission." in: American journal of physiology. Endocrinology and metabolism, Vol. 302, Issue 4, pp. E396-402, (2012) (PubMed).

Ketzef, Kahn, Weissberg, Becker, Friedman, Gitler: "Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice." in: Neuroscience, Vol. 189, pp. 108-22, (2011) (PubMed).

Synonyms and alternative names related to GAD

glutamate decarboxylase 1 (GAD1), glutamate decarboxylase 1 L homeolog (gad1.1.L), glutamate decarboxylase (GAD), glutamate decarboxylase 1 (Gad1), glutamate decarboxylase 1b (gad1b), CPSQ1, cpsq1, EP10, GAD, Gad-1, GAD-67, gad1, GAD1, gad1-A, GAD25, GAD44, gad67, GAD67, Gad67, GLUTAMATE DECARBOXYLASE, glutamate decarboxylase, GLUTAMATE DECARBOXYLASE 1, MKP11.30, MKP11_30, SCP

Protein level used designations for GAD

  • 67 kDa glutamic acid decarboxylase
  • GAD-67
  • glutamate decarboxylase 1
  • glutamate decarboxylase 67 kDa isoform
  • glutamic acid decarboxylase
  • glutamate decarboxylase, 67 kDa isoform
  • glutamic acid decarboxylase 1
  • glutamate decarboxylase 67
  • GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE)
  • Glutamate decarboxylase 1 (brain)
  • glutamate decarboxylase 1 variant GAD67NT
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