FZR1 Products
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Categories
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage leads to the ubiquitination of PLK1, preventing entry into mitosis (By similarity).
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Featured FZR1 Categories
FZR1 Antibodies
High quality antibodies with extensive validation data.
FZR1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FZR1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), PLA
Validations
- (5)
Cat. No.
ABIN526652
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (1)
- (5)
Cat. No.
ABIN2784494
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
- (3)
Cat. No.
ABIN1714172
Quantity
100 μL
Datasheet
Datasheet
Recommended FZR1 ELISA Kits
Recommended FZR1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354595
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354593
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3092674
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our FZR1 products
: "APC-Cdh1 Regulates Neuronal Apoptosis Through Modulating Glycolysis and Pentose-Phosphate Pathway After Oxygen-Glucose Deprivation and Reperfusion." in: Cellular and molecular neurobiology, Vol. 39, Issue 1, pp. 123-135, (2019) (PubMed).: "Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 19, pp. 9423-9432, (2019) (PubMed).
: "Inhibition of neddylation causes meiotic arrest in mouse oocyte." in: Cell cycle (Georgetown, Tex.), Vol. 18, Issue 11, pp. 1254-1267, (2019) (PubMed).
: "G1/S phase progression is regulated by PLK1 degradation through the CDK1/βTrCP axis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 31, Issue 7, pp. 2925-2936, (2017) (PubMed).
: "Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival." in: Scientific reports, Vol. 6, pp. 31158, (2016) (PubMed).
: "Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats." in: Molecular pain, Vol. 12, (2016) (PubMed).
: "Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway." in: Nature communications, Vol. 5, pp. 3480, (2014) (PubMed).
Synonyms and alternative names related to FZR1
fizzy and cell division cycle 20 related 1 (Fzr1), fizzy/cell division cycle 20 related 1 (CDH1-C), fizzy and cell division cycle 20 related 1 (FZR1), fizzy-related protein homolog (LOC100027495), fizzy-related protein homolog (LOC100179951), fizzy/cell division cycle 20 related 1 (Drosophila) (Fzr1), fizzy/cell division cycle 20 related 1a (fzr1a), AW108046, CDC20C, CDH1, Cdh1, CDH1-C, FYR, Fyr, FZR, fzr1, FZR2, HCDH, HCDH1, zgc:55450Protein level used designations for FZR1
- fizzy-related protein homolog
- fizzy/cell division cycle 20 related 1 (Drosophila)
- fizzy-related protein FZR
- Fizzy-related protein-like protein
- fizzy/cell division cycle 20 related 1
- CDC20-like 1b
- CDC20-like protein 1
- cdh1/Hct1 homolog
- cell division cycle 20 related 1
Did you look for something else?
- FZD9
- FZD7
- FZD6
- FZD5
- FZD4
- FZD3
- FZD2
- FZD1
- Fyv7p
- FYV10
- FYTTD1
- FYN
- FYCO1
- FYB1
- FYB
- FXYD7
- FXYD6P3
- FXYD6
- FXYD5
- FXYD4
- G Antigen 1
- G Antigen 10
- G Antigen 12B
- G Antigen 12F
- G Antigen 12G
- G Antigen 12H
- G Antigen 12I
- G Antigen 12J
- G Antigen 13
- G Antigen 2A
- G Antigen 2C
- G Antigen 2D
- G Antigen 4
- G Antigen 5
- G Antigen 7
- G Kinase Anchoring Protein 1
- G Protein-Coupled Receptor 1
- G Protein-Coupled Receptor 110
- G Protein-Coupled Receptor 115
- G Protein-Coupled Receptor 116
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