FZD6 Products
(Frizzled Family Receptor 6 (FZD6))
Categories
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011].
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Featured FZD6 Categories
FZD6 Antibodies
High quality antibodies with extensive validation data.
FZD6 ELISA Kits
Reliable ELISA kits for a wide range of species.
FZD6 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FZD6 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6258792
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey
Application
IHC, ICC, IHC (p)
Validations
- (3)
Cat. No.
ABIN1048614
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN1713791
Quantity
100 μL
Datasheet
Datasheet
Recommended FZD6 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955999
Quantity
96 tests
Datasheet
Datasheet
Recommended FZD6 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354586
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7398062
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
Cat. No.
ABIN7317167
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our FZD6 products
: "Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment." in: The Journal of biological chemistry, Vol. 293, Issue 46, pp. 17875-17887, (2018) (PubMed).: "A role for core planar polarity proteins in cell contact-mediated orientation of planar cell division across the mammalian embryonic skin." in: Scientific reports, Vol. 7, Issue 1, pp. 1880, (2017) (PubMed).
: "Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function." in: Respiratory research, Vol. 18, Issue 1, pp. 152, (2017) (PubMed).
: "Cell and Tissue Scale Forces Coregulate Fgfr2-Dependent Tetrads and Rosettes in the Mouse Embryo." in: Biophysical journal, Vol. 112, Issue 10, pp. 2209-2218, (2017) (PubMed).
: "The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation." in: Developmental biology, Vol. 409, Issue 1, pp. 181-93, (2015) (PubMed).
: "Anisotropic stress orients remodelling of mammalian limb bud ectoderm." in: Nature cell biology, Vol. 17, Issue 5, pp. 569-79, (2015) (PubMed).
: "Otitis media in sperm-associated antigen 6 (Spag6)-deficient mice." in: PLoS ONE, Vol. 9, Issue 11, pp. e112879, (2014) (PubMed).
: "Restoration of WNT4 inhibits cell growth in leukemia-derived cell lines." in: BMC cancer, Vol. 13, pp. 557, (2013) (PubMed).
: "Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain." in: Development (Cambridge, England), Vol. 138, Issue 8, pp. 1607-17, (2011) (PubMed).
: "Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer." in: British journal of cancer, Vol. 100, Issue 7, pp. 1165-74, (2009) (PubMed).
Synonyms and alternative names related to FZD6
frizzled class receptor 6 (fzd6), frizzled class receptor 6 S homeolog (fzd6.S), frizzled class receptor 6 (FZD6), frizzled class receptor 6 (Fzd6), frizzled-6, Frizzled-6, frizzled6, frz6, FZ-6, fz6, FZ6, Fz6, HFZ6, NDNC10, Xfrz6, zgc:65879, zgc:77440Protein level used designations for FZD6
- frizzled-6
- frizzled homolog 6
- frizzled 6
- frizzled 6, seven transmembrane spanning receptor
- seven transmembrane helix receptor
- fz-6
- involved in Wnt signaling, encoding a Wnt receptor
- mFz6
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