FZD1 Products
(Frizzled Family Receptor 1 (Fzd1))
Categories
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.
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Featured FZD1 Categories
FZD1 Antibodies
High quality antibodies with extensive validation data.
FZD1 ELISA Kits
Reliable ELISA kits for a wide range of species.
FZD1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FZD1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (8)
Cat. No.
ABIN7435805
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7153179
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7153175
Quantity
100 μg
Datasheet
Datasheet
Recommended FZD1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966904
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955998
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730674
Quantity
96 tests
Datasheet
Datasheet
Recommended FZD1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Human Cells
Validations
- (1)
Cat. No.
ABIN7320532
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7195855
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Human Cells
Validations
Cat. No.
ABIN4371866
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our FZD1 products
: "Overexpression of FZD1 and CAIX are Associated with Invasion, Metastasis, and Poor-Prognosis of the Pancreatic Ductal Adenocarcinoma." in: Pathology oncology research : POR, Vol. 24, Issue 4, pp. 899-906, (2018) (PubMed).: "Transcriptional Regulation of Frizzled-1 in Human Osteoblasts by Sp1." in: PLoS ONE, Vol. 11, Issue 10, pp. e0163277, (2017) (PubMed).
: "β-Catenin-dependent pathway activation by both promiscuous "canonical" WNT3a-, and specific "noncanonical" WNT4- and WNT5a-FZD receptor combinations with strong differences in LRP5 and LRP6 ..." in: Cellular signalling, Vol. 26, Issue 2, pp. 260-7, (2013) (PubMed).
: "Functional and association analysis of frizzled 1 (FZD1) promoter haplotypes with femoral neck geometry." in: Bone, Vol. 46, Issue 4, pp. 1131-7, (2010) (PubMed).
: "Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer." in: British journal of cancer, Vol. 100, Issue 7, pp. 1165-74, (2009) (PubMed).
: "A cryptic frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling." in: PLoS ONE, Vol. 3, Issue 4, pp. e1878, (2008) (PubMed).
: "Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis." in: American journal of respiratory cell and molecular biology, Vol. 37, Issue 3, pp. 309-21, (2007) (PubMed).
: "R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 37, pp. 14700-5, (2007) (PubMed).
: "Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation." in: Journal of cellular biochemistry, Vol. 101, Issue 5, pp. 1109-24, (2007) (PubMed).
: "Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes." in: Journal of dermatological science, Vol. 42, Issue 2, pp. 111-9, (2006) (PubMed).
Synonyms and alternative names related to FZD1
frizzled (fz), frizzled class receptor 1 (FZD1), frizzled class receptor 1 (Fzd1), frizzled class receptor 1 L homeolog (fzd1.L), AW227548, cFz-1, CG3646, CG17697, DFz, DFZ1, DFz1, Dfz1, Dmel\\CG17697, Dm Fz1, frizzled1, Frz, frz, frz-1, frz1, FZ, Fz, Fz-1, FZ-1, Fz1, fz1, fzd1-A, fz[[1]], Xfrizzled-1Protein level used designations for FZD1
- CG17697-PA
- CG17697-PB
- CG17697-PC
- Frizzled1
- frazzled
- frizzled 1
- frizzled[[1]]
- fz-PA
- fz-PB
- fz-PC
- frizzled 1, seven transmembrane spanning receptor
- frizzled homolog 1
- Wnt receptor
- frizzled, Drosophila, homolog of, 1
- frizzled-1
- fz-1
- fzE1
- hFz1
- 7-transmembrane protein frizzled-1
- Drosophila polarity gene (frizzled) homologue
- Drosophila polarity gene homolog 1
- rFz1
- 7-transmembrane receptor frizzled-1
- xfz1
- mFz1
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