FXYD5 Products
(FXYD Domain Containing Ion Transport Regulator 5 (FXYD5))
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This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009].
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Featured FXYD5 Categories
FXYD5 Antibodies
High quality antibodies with extensive validation data.
FXYD5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FXYD5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Saccharomyces cerevisiae
Application
WB
Validations
- (1)
- (3)
Cat. No.
ABIN2780210
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7153251
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN184712
Quantity
100 μg
Datasheet
Datasheet
Recommended FXYD5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN1098542
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2129321
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our FXYD5 products
: "Fxyd5 activates the NF‑κB pathway and is involved in chondrocytes inflammation and extracellular matrix degradation." in: Molecular medicine reports, Vol. 25, Issue 4, (2022) (PubMed).: "FXYD5 modulates Na+ absorption and is increased in cystic fibrosis airway epithelia." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 294, Issue 4, pp. L654-64, (2008) (PubMed).
: "Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion." in: Glycobiology, Vol. 13, Issue 7, pp. 521-7, (2003) (PubMed).
: "Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 1, pp. 365-70, (2002) (PubMed).
Synonyms and alternative names related to FXYD5
FXYD domain containing ion transport regulator 5 (FXYD5), FXYD domain-containing ion transport regulator 5 (Fxyd5), DYSAD, EF-8, FXYD5, IWU1, KCT1, OIT2, Oit2, PRO6241, RICProtein level used designations for FXYD5
- FXYD domain-containing ion transport regulator 5
- FXYD domain containing ion transport regulator 5
- dysadherin
- keratinocytes associated transmembrane protein 1
- ion channel homolog RIC
- oncoprotein induced transcript 2
- oncoprotein-induced protein 2
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