FXYD1 Products
(FXYD Domain Containing Ion Transport Regulator 1 (FXYD1))
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This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008].
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Featured FXYD1 Categories
FXYD1 Antibodies
High quality antibodies with extensive validation data.
FXYD1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FXYD1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7236228
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (4)
Cat. No.
ABIN3043831
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB
Validations
- (1)
- (1)
Cat. No.
ABIN1882173
Quantity
400 μL
Datasheet
Datasheet
Recommended FXYD1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2728859
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our FXYD1 products
: "Phospholemman and beta-adrenergic stimulation in the heart." in: American journal of physiology. Heart and circulatory physiology, Vol. 298, Issue 3, pp. H807-15, (2010) (PubMed).: "FXYD1, a modulator of Na,K-ATPase activity, facilitates female sexual development by maintaining gonadotrophin-releasing hormone neuronal excitability." in: Journal of neuroendocrinology, Vol. 21, Issue 2, pp. 108-22, (2009) (PubMed).
: "Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman." in: American journal of physiology. Cell physiology, Vol. 297, Issue 3, pp. C699-705, (2009) (PubMed).
: "Left ventricular function of isoproterenol-induced hypertrophied rat hearts perfused with blood: mechanical work and energetics." in: American journal of physiology. Heart and circulatory physiology, Vol. 297, Issue 5, pp. H1736-43, (2009) (PubMed).
Synonyms and alternative names related to FXYD1
FXYD domain containing ion transport regulator 1 (FXYD1), FXYD domain-containing ion transport regulator 1 (Fxyd1), 0610012C17Rik, 1110006M24Rik, PLM, Plm, PmlProtein level used designations for FXYD1
- FXYD domain containing ion transport regulator 1
- phospholemman
- FXYD domain containing ion transport regulator 1 (phospholemman)
- FXYD domain-containing ion transport regulator 1
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