FURIN Products
(Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))
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The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].
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Featured FURIN Categories
FURIN Antibodies
High quality antibodies with extensive validation data.
FURIN ELISA Kits
Reliable ELISA kits for a wide range of species.
FURIN Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FURIN Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, IF
Validations
- (6)
Cat. No.
ABIN6140815
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7442045
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7437320
Quantity
100 μL
Datasheet
Datasheet
Recommended FURIN ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (5)
Cat. No.
ABIN6574306
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966913
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966912
Quantity
96 tests
Datasheet
Datasheet
Recommended FURIN Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1354517
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123019
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN934971
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our FURIN products
: "TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions." in: Cell reports, Vol. 28, Issue 12, pp. 3077-3091.e5, (2019) (PubMed).: "Pharmacological Manipulation of Trk, p75NTR, and NGF Balance Restores Memory Deficit in Global Ischemia/Reperfusion Model in Rats." in: Journal of molecular neuroscience : MN, Vol. 68, Issue 1, pp. 78-90, (2019) (PubMed).
: "Prolonged circulation and increased tumor accumulation of liposomal vincristine in a mouse model of rhabdomyosarcoma." in: Nanomedicine (London, England), Vol. 12, Issue 10, pp. 1135-1151, (2017) (PubMed).
: "Antibody-Array-Based Proteomic Screening of Serum Markers in Systemic Lupus Erythematosus: A Discovery Study." in: Journal of proteome research, Vol. 15, Issue 7, pp. 2102-14, (2016) (PubMed).
: "Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity." in: Analytical biochemistry, Vol. 475, pp. 14-21, (2015) (PubMed).
: "Diagnostic utility of BNP, corin and furin as biomarkers for cardiovascular complications in type 2 diabetes mellitus patients." in: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, Vol. 20, Issue 6-7, pp. 460-9, (2015) (PubMed).
: "The effects of cytokines on spontaneous hepatitis B surface antigen seroconversion in chronic hepatitis B virus infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 2, pp. 690-6, (2015) (PubMed).
: "Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing." in: PLoS ONE, Vol. 9, Issue 1, pp. e84958, (2014) (PubMed).
: "The eukaryotic signal sequence, YGRL, targets the chlamydial inclusion." in: Frontiers in cellular and infection microbiology, Vol. 4, pp. 129, (2014) (PubMed).
: "Proprotein convertases process and thereby inactivate formylglycine-generating enzyme." in: The Journal of biological chemistry, Vol. 288, Issue 8, pp. 5828-39, (2013) (PubMed).
Synonyms and alternative names related to FURIN
furin, paired basic amino acid cleaving enzyme (FURIN), furin (paired basic amino acid cleaving enzyme) a (furina), furin (paired basic amino acid cleaving enzyme) b (furinb), furin, paired basic amino acid cleaving enzyme (furin), furin, paired basic amino acid cleaving enzyme L homeolog (furin.L), furin (paired basic amino acid cleaving enzyme) (Furin), 9130404I01Rik, FUR, Fur, FURIN, furin, LOC100220259, MGC82710, PACE, Pace, PCSK3, Pcsk3, si:dkey-281a24.5, spc1, SPC1, xfurinProtein level used designations for FURIN
- furin (paired basic amino acid cleaving enzyme)
- furin A
- stu
- sturgeon
- furin B
- furin
- furin-like
- FES upstream region
- dibasic processing enzyme
- dibasic-processing enzyme
- furin, membrane associated receptor protein
- paired basic amino acid residue-cleaving enzyme
- proprotein convertase subtilisin/kexin type 3
- paired basic amino acid residue cleaving enzyme
- prohormone convertase 3
- subtilisin pro-protein processing enzyme
- paired basic amino acid cleaving enzyme
- trans Golgi network protease furin
- Paired basic amino acid cleaving enzyme (furin)
- Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein)
- proprotein convertase subtilisin/kexin type3
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