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FTO Products

(Fat Mass and Obesity-Associated (FTO))
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011].

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Featured FTO Categories

FTO Antibodies

High quality antibodies with extensive validation data.

FTO ELISA Kits

Reliable ELISA kits for a wide range of species.

FTO Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FTO Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7127502
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), FACS
Validations
  • (3)
Cat. No. ABIN390964
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IP
Validations
  • (3)
Cat. No. ABIN1169073
Quantity 100 μg
Datasheet Datasheet

Recommended FTO ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966656
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5594574
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6228458
Quantity 96 tests
Datasheet Datasheet

Recommended FTO Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354483
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN1344345
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN1344349
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our FTO products

Mao, Dong, Liu, Guo, Ma, Shen, Qian: "m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2." in: Nature communications, Vol. 10, Issue 1, pp. 5332, (2020) (PubMed).

Liu, Zhou, Mao, Ji, Qian: "Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates." in: Nature chemical biology, Vol. 15, Issue 9, pp. 865-871, (2019) (PubMed).

Zhou, Wan, Shu, Mao, Liu, Yuan, Zhang, Hess, Brüning, Qian: "N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response." in: Molecular cell, Vol. 69, Issue 4, pp. 636-647.e7, (2019) (PubMed).

Wang, Li, Yue, Wang, Kumar, Wechsler-Reya, Zhang, Ogawa, Kellis, Duester, Zhao: "N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications." in: Nature neuroscience, Vol. 21, Issue 2, pp. 195-206, (2019) (PubMed).

Yu, Chen, Huang, Zhu, Song, Zhu, Park, Ji: "Dynamic m6A modification regulates local translation of mRNA in axons." in: Nucleic acids research, Vol. 46, Issue 3, pp. 1412-1423, (2019) (PubMed).

Walters, Mercaldo, Gillon, Yip, Neve, Boyce, Frankland, Josselyn: "The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 42, Issue 7, pp. 1502-1510, (2017) (PubMed).

Wang, Shie, Hsieh, Tsai, Wen: "FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription." in: Biochemical and biophysical research communications, Vol. 464, Issue 3, pp. 826-32, (2015) (PubMed).

Berulava, Rahmann, Rademacher, Klein-Hitpass, Horsthemke: "N6-adenosine methylation in MiRNAs." in: PLoS ONE, Vol. 10, Issue 2, pp. e0118438, (2015) (PubMed).

Zhou, Wan, Gao, Zhang, Jaffrey, Qian: "Dynamic m(6)A mRNA methylation directs translational control of heat shock response." in: Nature, Vol. 526, Issue 7574, pp. 591-4, (2015) (PubMed).

Gerken, Girard, Tung, Webby, Saudek, Hewitson, Yeo, McDonough, Cunliffe, McNeill, Galvanovskis, Rorsman, Robins, Prieur, Coll, Ma, Jovanovic, Farooqi, Sedgwick, Barroso, Lindahl, Ponting, Ashcroft et al.: "The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. ..." in: Science (New York, N.Y.), Vol. 318, Issue 5855, pp. 1469-72, (2007) (PubMed).

Synonyms and alternative names related to FTO

FTO, alpha-ketoglutarate dependent dioxygenase (FTO), fat mass and obesity associated (Fto), FTO, alpha-ketoglutarate dependent dioxygenase (Fto), fat mass and obesity associated L homeolog (fto.L), AW743446, mKIAA1752, RGD1305121

Protein level used designations for FTO

  • alpha-ketoglutarate-dependent dioxygenase FTO
  • fat mass and obesity-associated protein
  • protein fto
  • protein fatso
  • fat mass and obesity associated protein
  • Protein fatso
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