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FMO3 Products

(Flavin Containing Monooxygenase 3 (FMO3))

Categories

Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Aug 2009].

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Featured FMO3 Categories

FMO3 Antibodies

High quality antibodies with extensive validation data.

FMO3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FMO3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (5)
Cat. No. ABIN7267216
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), FACS
Validations
  • (3)
Cat. No. ABIN390888
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (3)
Cat. No. ABIN515768
Quantity 50 μg
Datasheet Datasheet

Recommended FMO3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354250
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7423360
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2721250
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our FMO3 products

Ganti, Skapek, Zhang, Fuller, Wu, Billups, Breitfeld, Dalton, Meyer, Khoury: "Expression and genomic status of EGFR and ErbB-2 in alveolar and embryonal rhabdomyosarcoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 19, Issue 9, pp. 1213-20, (2006) (PubMed).

Cashman, Zhang: "Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 30, Issue 10, pp. 1043-52, (2002) (PubMed).

Synonyms and alternative names related to FMO3

flavin containing monooxygenase 3 (FMO3), flavin containing monooxygenase 3 (fmo3), flavin containing monooxygenase 3 L homeolog (fmo3.L), flavin containing monooxygenase 3 (Fmo3), AW111792, dJ127D3.1, FM03, FMOII, MGC107820, TMAU

Protein level used designations for FMO3

  • dimethylaniline monooxygenase [N-oxide-forming] 3
  • flavin containing monooxygenase 3
  • FMO 3
  • FMO II
  • FMO form 2
  • dimethylaniline oxidase 3
  • hepatic flavin-containing monooxygenase 3
  • hepatic flavin-containing monooxygenase-3
  • trimethylamine monooxygenase
  • flavin-containing monooxygenase 3
  • FMO 1D1
  • flavin-containing monooxygenase FMO3
  • flavin-containing monooxygenase form 3
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