FLT3 Products
(Fms-Related tyrosine Kinase 3 (FLT3))
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This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008].
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Featured FLT3 Categories
FLT3 Antibodies
High quality antibodies with extensive validation data.
FLT3 ELISA Kits
Reliable ELISA kits for a wide range of species.
FLT3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FLT3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
- (4)
Cat. No.
ABIN1724846
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IHC (p)
Validations
- (6)
Cat. No.
ABIN5518988
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN7012052
Quantity
60 μL
Datasheet
Datasheet
Recommended FLT3 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955938
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
Cat. No.
ABIN6730593
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966839
Quantity
96 tests
Datasheet
Datasheet
Recommended FLT3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (5)
Cat. No.
ABIN7274657
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274655
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274660
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our FLT3 products
: "Rationale for a Combination Therapy Consisting of MCL1- and MEK-Inhibitors in Acute Myeloid Leukemia." in: Cancers, Vol. 11, Issue 11, (2019) (PubMed).: "Alpha-1 Antitrypsin Prevents the Development of Preeclampsia Through Suppression of Oxidative Stress." in: Frontiers in physiology, Vol. 7, pp. 176, (2016) (PubMed).
: "A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling." in: Leukemia, Vol. 27, Issue 12, pp. 2301-10, (2013) (PubMed).
: "Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 8, pp. 3822-30, (2012) (PubMed).
: "Influence of FLT3-internal tandem duplication allele burden and white blood cell count on the outcome in patients with intermediate-risk karyotype acute myeloid leukemia." in: Cancer, Vol. 118, Issue 24, pp. 6110-7, (2012) (PubMed).
: "Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia." in: Blood, Vol. 120, Issue 15, pp. 3069-79, (2012) (PubMed).
: "Mesenchymal stem cells originating from ES cells show high telomerase activity and therapeutic benefits." in: Differentiation; research in biological diversity, Vol. 82, Issue 3, pp. 153-64, (2011) (PubMed).
: "Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 10918-29, (2011) (PubMed).
: "A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 12, pp. 8126-34, (2008) (PubMed).
: "Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling." in: British journal of haematology, Vol. 141, Issue 4, pp. 483-93, (2008) (PubMed).
Synonyms and alternative names related to FLT3
fms related tyrosine kinase 3 (FLT3), FMS-like tyrosine kinase 3 (Flt3), fms-related tyrosine kinase 3 (Flt3), fms related tyrosine kinase 3 (Flt3), B230315G04, CD135, Flk-2, FLK-2, Flk2, FLK2, Flt-3, FLT3, Ly72, STK1, wmflProtein level used designations for FLT3
- fms-related tyrosine kinase 3
- FL cytokine receptor-like
- FL cytokine receptor
- fetal liver kinase 2
- receptor-type tyrosine-protein kinase FLT3
- tyrosine-protein kinase FLT3
- tyrosine-protein kinase receptor flk-2
- CD135 antigen
- STK-1
- fms-like tyrosine kinase 3
- growth factor receptor tyrosine kinase type III
- stem cell tyrosine kinase 1
- FMS-like tyrosine kinase 3
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