FLIP Products
(CASP8 and FADD-Like Apoptosis Regulator (CFLAR))
Categories
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011].
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Featured FLIP Categories
FLIP Antibodies
High quality antibodies with extensive validation data.
FLIP ELISA Kits
Reliable ELISA kits for a wide range of species.
FLIP Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FLIP Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, FACS
Validations
- (2)
- (6)
Cat. No.
ABIN1724850
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (7)
Cat. No.
ABIN563829
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7146901
Quantity
100 μg
Datasheet
Datasheet
Recommended FLIP ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965446
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954407
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6213279
Quantity
96 tests
Datasheet
Datasheet
Recommended FLIP Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1349226
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN935116
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1349225
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our FLIP products
: "Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4." in: Cell reports, Vol. 21, Issue 12, pp. 3427-3444, (2018) (PubMed).: "The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2." in: Molecular cell, Vol. 65, Issue 4, pp. 730-742.e5, (2017) (PubMed).
: "Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening." in: Breast cancer research : BCR, Vol. 16, Issue 2, pp. R41, (2014) (PubMed).
: "RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis." in: Nature, Vol. 513, Issue 7516, pp. 90-4, (2014) (PubMed).
: "Poor antibody validation is a challenge in biomedical research: a case study for detection of c-FLIP." in: Apoptosis : an international journal on programmed cell death, Vol. 18, Issue 10, pp. 1154-62, (2013) (PubMed).
: "Release of an ~55kDa fragment containing the actin-binding domain of ?-spectrin by caspase-8 during FND-induced apoptosis depends on the presence of protein 4.1." in: Archives of biochemistry and biophysics, Vol. 535, Issue 2, pp. 205-13, (2013) (PubMed).
: "Expression of c-FLIP in pulmonary metastases in osteosarcoma patients and human xenografts." in: Pediatric blood & cancer, Vol. 60, Issue 4, pp. 575-9, (2013) (PubMed).
: "Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence." in: PLoS ONE, Vol. 7, Issue 9, pp. e44917, (2012) (PubMed).
: "The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition." in: Cancer prevention research (Philadelphia, Pa.), Vol. 5, Issue 4, pp. 612-20, (2012) (PubMed).
: "CHOP down-regulates cFLIP(L) expression by promoting ubiquitin/proteasome-mediated cFLIP(L) degradation." in: Journal of cellular biochemistry, Vol. 113, Issue 12, pp. 3692-700, (2012) (PubMed).
Synonyms and alternative names related to FLIP
CASP8 and FADD-like apoptosis regulator a (cflara), CASP8 and FADD like apoptosis regulator (CFLAR), CASP8 and FADD like apoptosis regulator (cflar), CASP8 and FADD like apoptosis regulator S homeolog (cflar.S), CASP8 and FADD-like apoptosis regulator (Cflar), 2310024N18Rik, A430105C05Rik, c-FLIP, c-Flip, c-FLIPL, c-FLIPR, c-FLIPS, CASH, Cash, CASP8AP1, Casper, cflar, CFLAR, CLARP, Clarp1, ENSMUSG00000072980, FLAME, FLAME-1, FLAME1, FLIP, Flip, Gm9845, I-FLICE, MRITProtein level used designations for FLIP
- FLIP
- CASP8 and FADD-like apoptosis regulator
- flice/caspase-i inhibitory protein
- cellular FLICE-like inhibitory protein
- CASP8 and FADD-like apoptosis regulator-like
- FADD-like anti-apoptotic molecule
- FADD-like antiapoptotic molecule 1
- MACH-related inducer of toxicity
- caspase homolog
- caspase-eight-related protein
- caspase-like apoptosis regulatory protein
- caspase-related inducer of apoptosis
- inhibitor of FLICE
- usurpin beta
- usurpin
- FLICE-like inhibitory protein
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