FKBP4 Products
(FK506 Binding Protein 4, 59kDa (FKBP4))
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The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008].
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Featured FKBP4 Categories
FKBP4 Antibodies
High quality antibodies with extensive validation data.
FKBP4 ELISA Kits
Reliable ELISA kits for a wide range of species.
FKBP4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FKBP4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IP, ELISA, IHC (p)
Validations
- (2)
- (8)
Cat. No.
ABIN560907
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
- (7)
Cat. No.
ABIN7441208
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (8)
Cat. No.
ABIN949997
Quantity
100 μL
Datasheet
Datasheet
Recommended FKBP4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955922
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4882894
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1147317
Quantity
96 tests
Datasheet
Datasheet
Recommended FKBP4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1354126
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354128
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122976
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our FKBP4 products
: "The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets." in: Molecular & cellular proteomics : MCP, Vol. 13, Issue 12, pp. 3585-601, (2014) (PubMed).: "Cancer cell response to anthracyclines effects: mysteries of the hidden proteins associated with these drugs." in: International journal of molecular sciences, Vol. 13, Issue 12, pp. 15536-64, (2013) (PubMed).
: "Investigation of SSEA-4 binding protein in breast cancer cells." in: Journal of the American Chemical Society, Vol. 135, Issue 16, pp. 5934-7, (2013) (PubMed).
: "High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays." in: Journal of proteome research, Vol. 12, Issue 5, pp. 2311-20, (2013) (PubMed).
: "Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins." in: ACS chemical biology, Vol. 6, Issue 12, pp. 1357-66, (2011) (PubMed).
: "Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 14, pp. 4733-41, (2009) (PubMed).
: "Pharmacologic unmasking of epigenetically silenced genes in breast cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 4, pp. 1184-91, (2009) (PubMed).
: "Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 1, pp. 33-8, (2008) (PubMed).
: "The switch I region of Rheb is critical for its interaction with FKBP38." in: The Journal of biological chemistry, Vol. 283, Issue 38, pp. 25963-70, (2008) (PubMed).
Synonyms and alternative names related to FKBP4
FK506 binding protein 4 (FKBP4), FK506 binding protein 4 S homeolog (fkbp4.S), FK506 binding protein 4 (fkbp4), FK506 binding protein 4 (Fkbp4), 59kDa, AL022792, AW208983, FKBP-4, FKBP-52, FKBP51, fkbp52, FKBP52, fkbp59, FKBP59, FKPB52, HBI, hsp56, Hsp56, MGC81078, p52, p59, P59, PPIase, wu:fb34f09Protein level used designations for FKBP4
- peptidyl-prolyl cis-trans isomerase FKBP4
- FK506-binding protein 4
- FK506 binding protein 4, 59kDa
- peptidyl-prolyl cis-trans isomerase FKBP4-like
- 52 kDa FK506-binding protein
- 52 kDa FKBP
- 59 kDa immunophilin
- FKBP59
- HBI
- HSP-binding immunophilin
- PPIase FKBP4
- immunophilin FKBP52
- rotamase
- FK506 binding protein 52
- FKBP52 protein
- 51 kDa FK506-binding protein
- FK506-binding protein 4 (59kD)
- HSP binding immunophilin
- T-cell FK506-binding protein, 59kD
- peptidylprolyl cis-trans isomerase
- hsp90 binding protein
- p59 protein
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