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Fibrillarin Products

(Fibrillarin (FBL))
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008].

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Featured Fibrillarin Categories

Fibrillarin Antibodies

High quality antibodies with extensive validation data.

Fibrillarin ELISA Kits

Reliable ELISA kits for a wide range of species.

Fibrillarin Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Fibrillarin Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, IP, ICC
Validations
  • (5)
Cat. No. ABIN2855179
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IP
Validations
  • (5)
Cat. No. ABIN6140494
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (5)
Cat. No. ABIN7267175
Quantity 100 μL
Datasheet Datasheet

Recommended Fibrillarin ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966723
Quantity 96 tests
Datasheet Datasheet
Reactivity Guinea Pig
Analytical Method Quantitative
Validations
Cat. No. ABIN776788
Quantity 96 tests
Datasheet Datasheet
Reactivity Rabbit
Analytical Method Quantitative
Validations
Cat. No. ABIN774833
Quantity 96 tests
Datasheet Datasheet

Recommended Fibrillarin Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122909
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1778236
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7419130
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Fibrillarin products

Grimmer, Bacia: "Giant Endoplasmic Reticulum vesicles (GERVs), a novel model membrane tool." in: Scientific reports, Vol. 10, Issue 1, pp. 3100, (2020) (PubMed).

Vendramin, Verheyden, Ishikawa, Goedert, Nicolas, Saraf, Armaos, Delli Ponti, Izumikawa, Mestdagh, Lafontaine, Tartaglia, Takahashi, Marine, Leucci: "SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation." in: Nature structural & molecular biology, Vol. 25, Issue 11, pp. 1035-1046, (2019) (PubMed).

Tiku, Jain, Raz, Nakamura, Heestand, Liu, Späth, Suchiman, Müller, Slagboom, Partridge, Antebi: "Small nucleoli are a cellular hallmark of longevity." in: Nature communications, Vol. 8, pp. 16083, (2018) (PubMed).

Langhendries, Nicolas, Doumont, Goldman, Lafontaine: "The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis." in: Oncotarget, Vol. 7, Issue 37, pp. 59519-59534, (2018) (PubMed).

Tiku, Kew, Mehrotra, Ganesan, Robinson, Antebi: "Nucleolar fibrillarin is an evolutionarily conserved regulator of bacterial pathogen resistance." in: Nature communications, Vol. 9, Issue 1, pp. 3607, (2018) (PubMed).

Buchwalter, Hetzer: "Nucleolar expansion and elevated protein translation in premature aging." in: Nature communications, Vol. 8, Issue 1, pp. 328, (2017) (PubMed).

Itatani, Sonoshita, Kakizaki, Okawa, Stifani, Itoh, Sakai, Taketo: "Characterization of Aes nuclear foci in colorectal cancer cells." in: Journal of biochemistry, Vol. 159, Issue 1, pp. 133-40, (2016) (PubMed).

Mitrea, Cika, Guy, Ban, Banerjee, Stanley, Nourse, Deniz, Kriwacki: "Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA." in: eLife, Vol. 5, (2016) (PubMed).

Robaszkiewicz, Idziak-Helmcke, Tkacz, Chrominski, Hasterok: "The arrangement of Brachypodium distachyon chromosomes in interphase nuclei." in: Journal of experimental botany, Vol. 67, Issue 18, pp. 5571-5583, (2016) (PubMed).

Dolma, Selvadurai, Lan, Lee, Kushida, Voisin, Whetstone, So, Aviv, Park, Zhu, Xu, Head, Rowland, Bernstein, Clarke, Bader, Harrington, Brumell, Tyers, Dirks: "Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells." in: Cancer cell, Vol. 29, Issue 6, pp. 859-73, (2016) (PubMed).

Synonyms and alternative names related to Fibrillarin

fibrillarin (FBL), fibrillarin (fbl), fibrillarin (Fbl), Fibrillarin (Fib), fibrillarin (fib1), putative fibrillarin (LMJF_19_0100), fibrillarin S homeolog (fbl.S), AL022665, CG9888, Dmel\\CG9888, FBL, fbl, FIB, fib, Fibri, FLRN, GCR-6, GCR6, MGC76139, Pen59C5, pen59C5, RNU3IP1, wu:fb37g12, zgc:56145, zgc:77130

Protein level used designations for Fibrillarin

  • 34 kDa nucleolar scleroderma antigen
  • 34-kD nucleolar scleroderma antigen
  • RNA, U3 small nucleolar interacting protein 1
  • rRNA 2'-O-methyltransferase fibrillarin
  • fb37g12
  • nucleolar protein 1
  • fibrillarin
  • CG9888-PA
  • Fib-PA
  • FIB
  • histone-glutamine methyltransferase
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