FHIT Products
(Fragile Histidine Triad (FHIT))
Categories
This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009].
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Featured FHIT Categories
FHIT Antibodies
High quality antibodies with extensive validation data.
FHIT ELISA Kits
Reliable ELISA kits for a wide range of species.
FHIT Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FHIT Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB
Validations
- (4)
Cat. No.
ABIN3021692
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
- (4)
Cat. No.
ABIN3042392
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
ELISA, WB, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6261741
Quantity
100 μL
Datasheet
Datasheet
Recommended FHIT ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6975306
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381137
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951726
Quantity
96 tests
Datasheet
Datasheet
Recommended FHIT Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123000
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354070
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2129260
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our FHIT products
: "FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension." in: American journal of respiratory and critical care medicine, Vol. 199, Issue 1, pp. 83-98, (2019) (PubMed).: "FHIT promoter methylation status, low protein and high mRNA levels in patients with non-small cell lung cancer." in: International journal of oncology, Vol. 49, Issue 3, pp. 1175-84, (2016) (PubMed).
: "High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis." in: Neoplasia (New York, N.Y.), Vol. 14, Issue 9, pp. 788-98, (2012) (PubMed).
: "CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine." in: Biochemical and biophysical research communications, Vol. 402, Issue 3, pp. 507-14, (2010) (PubMed).
: "Neuroprotective properties of picroside II in a rat model of focal cerebral ischemia." in: International journal of molecular sciences, Vol. 11, Issue 11, pp. 4580-90, (2010) (PubMed).
: "The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas." in: Cancer genomics & proteomics, Vol. 5, Issue 6, pp. 293-300, (2009) (PubMed).
: "Muir-Torre-like syndrome in Fhit-deficient mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 9, pp. 4742-7, (2000) (PubMed).
: "The Fhit tumor suppressor protein regulates the intracellular concentration of diadenosine triphosphate but not diadenosine tetraphosphate." in: Cancer research, Vol. 60, Issue 9, pp. 2342-4, (2000) (PubMed).
: "The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers." in: Cell, Vol. 84, Issue 4, pp. 587-97, (1996) (PubMed).
: "Coxsackievirus B3: primary structure of the 5' non-coding and capsid protein-coding regions of the genome." in: Virus research, Vol. 3, Issue 3, pp. 263-70, (1986) (PubMed).
Synonyms and alternative names related to FHIT
fragile histidine triad (FHIT), fragile histidine triad (Fhit), fragile histidine triad gene (fhit), fragile histidine triad gene (Fhit), fragile histidine triad (fhit), fragile histidine triad protein (PY07476), fragile histidine triad L homeolog (fhit.L), AP3Aase, AW045638, FHIT, FRA3B, Fra14A2, LOC100223655, zgc:73176Protein level used designations for FHIT
- AP3A hydrolase
- bis(5'-adenosyl)-triphosphatase
- diadenosine 5',5'''-P1,P3-triphosphate hydrolase
- dinucleosidetriphosphatase
- tumor suppressor protein
- AP3Aase
- fragile histidine triad protein
- fragile histidine triad gene
- diadenosine triphosphate hydrolase
- fragile histidine triad
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