FGFR4 Products
(Fibroblast Growth Factor Receptor 4 (FGFR4))
Categories
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008].
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Featured FGFR4 Categories
FGFR4 Antibodies
High quality antibodies with extensive validation data.
FGFR4 ELISA Kits
Reliable ELISA kits for a wide range of species.
FGFR4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FGFR4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IHC (p)
Validations
- (5)
Cat. No.
ABIN391970
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (5)
Cat. No.
ABIN7193467
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (4)
Cat. No.
ABIN7193466
Quantity
100 μL
Datasheet
Datasheet
Recommended FGFR4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6955881
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966794
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5526795
Quantity
96 tests
Datasheet
Datasheet
Recommended FGFR4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274619
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274631
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rhesus Monkey
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274612
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our FGFR4 products
: "Raspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet." in: The Journal of nutritional biochemistry, Vol. 46, pp. 13-20, (2017) (PubMed).: "FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis." in: Human molecular genetics, Vol. 24, Issue 12, pp. 3506-17, (2015) (PubMed).
: "A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation." in: Cellular and molecular life sciences : CMLS, (2015) (PubMed).
: "FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver." in: Diabetes, Vol. 56, Issue 10, pp. 2501-10, (2007) (PubMed).
: "Targeting N-cadherin through fibroblast growth factor receptor-4: distinct pathogenetic and therapeutic implications." in: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 11, pp. 2965-75, (2006) (PubMed).
: "FGFR4 Arg388 allele correlates with tumour thickness and FGFR4 protein expression with survival of melanoma patients." in: British journal of cancer, Vol. 94, Issue 12, pp. 1879-86, (2006) (PubMed).
: "Telling the liver (not) to make bile acids: a new voice from the gut?" in: Cell metabolism, Vol. 2, Issue 4, pp. 209-10, (2005) (PubMed).
: "G388R mutation of the FGFR4 gene is not relevant to breast cancer prognosis." in: British journal of cancer, Vol. 90, Issue 1, pp. 189-93, (2004) (PubMed).
: "Cytoplasmic expression of fibroblast growth factor receptor-4 in human pituitary adenomas: relation to tumor type, size, proliferation, and invasiveness." in: The Journal of clinical endocrinology and metabolism, Vol. 89, Issue 4, pp. 1904-11, (2004) (PubMed).
: "Pituitary tumor AP-2alpha recognizes a cryptic promoter in intron 4 of fibroblast growth factor receptor 4." in: The Journal of biological chemistry, Vol. 278, Issue 22, pp. 19597-602, (2003) (PubMed).
Synonyms and alternative names related to FGFR4
fibroblast growth factor receptor 4 (FGFR4), fibroblast growth factor receptor 4 (fgfr4), fibroblast growth factor receptor 4 (Fgfr4), fibroblast growth factor receptor 4 S homeolog (fgfr4.S), cd334, CD334, etID309818.21, fgfr-4, Fgfr-4, fgfr-4c, FGFR4, fgfr4, jtk2, JTK2, tkf, TKF, wu:fc13h10, XFGFR-4, XFGFR-4a, xfgfr4, zgc:111935Protein level used designations for FGFR4
- fibroblast growth factor receptor 4
- FGF receptor 4
- FGFR-4
- hydroxyaryl-protein kinase
- protein-tyrosine kinase
- tyrosine kinase related to fibroblast growth factor receptor
- tyrosylprotein kinase
- CTLA-2-beta protein
- fibroblast growth factor receptor 4 16 minus form
- protein-tyrosine kinase receptor MPK-11
- fibroblast growth factor receptor FREK
- fibroblast growth factor receptor-like embryonic kinase
- fibroblast growth factor receptor 4c
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