FGFR1 Products
(Fibroblast Growth Factor Receptor 1 (FGFR1))
Categories
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
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Featured FGFR1 Categories
FGFR1 Antibodies
High quality antibodies with extensive validation data.
FGFR1 ELISA Kits
Reliable ELISA kits for a wide range of species.
FGFR1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FGFR1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, IHC (p), FACS
Validations
- (12)
- (4)
Cat. No.
ABIN1882081
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7434056
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (5)
Cat. No.
ABIN6261731
Quantity
100 μL
Datasheet
Datasheet
Recommended FGFR1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6955877
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966791
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966790
Quantity
96 tests
Datasheet
Datasheet
Recommended FGFR1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7274633
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (3)
Cat. No.
ABIN1589526
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Mammalian Cells
Validations
- (1)
Cat. No.
ABIN7538233
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our FGFR1 products
: "Fibroblast growth factor-2/platelet-derived growth factor enhances atherosclerotic plaque stability." in: Journal of cellular and molecular medicine, Vol. 24, Issue 1, pp. 1128-1140, (2020) (PubMed).: "Fibroblast growth factor 21 ameliorates vascular calcification by inhibiting osteogenic transition in vitamin D3 plus nicotine-treated rats." in: Biochemical and biophysical research communications, Vol. 495, Issue 4, pp. 2448-2455, (2018) (PubMed).
: "Protection Effect of Exogenous Fibroblast Growth Factor 21 on the Kidney Injury in Vascular Calcification Rats." in: Chinese medical journal, Vol. 131, Issue 5, pp. 532-538, (2018) (PubMed).
: "Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens." in: Scientific reports, Vol. 8, Issue 1, pp. 3680, (2018) (PubMed).
: "Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium." in: PLoS ONE, Vol. 12, Issue 8, pp. e0183181, (2017) (PubMed).
: "Synergistic suppression of a disintegrin acurhagin-C in combination with AZD4547 and reparixin on terminating development for human osteosarcoma MG-63 cell." in: Biochemical and biophysical research communications, Vol. 492, Issue 3, pp. 513-519, (2017) (PubMed).
: "Association of fibroblast growth factor receptor 1 gene amplification with poor survival in patients with esophageal squamous cell carcinoma." in: Oncotarget, Vol. 8, Issue 51, pp. 88857-88869, (2017) (PubMed).
: "TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons." in: The EMBO journal, Vol. 35, Issue 21, pp. 2350-2370, (2016) (PubMed).
: "Combination treatment of prostate cancer with FGF receptor and AKT kinase inhibitors." in: Oncotarget, Vol. 8, Issue 4, pp. 6179-6192, (2016) (PubMed).
: "Homeobox family Hoxc localization during murine palate formation." in: Congenital anomalies, Vol. 56, Issue 4, pp. 172-9, (2016) (PubMed).
Synonyms and alternative names related to FGFR1
fibroblast growth factor receptor (FGFR), fibroblast growth factor receptor (fgfr), fibroblast growth factor receptor 1 S homeolog (fgfr1.S), basic fibroblast growth factor receptor 1 (CpipJ_CPIJ005849), heartless (htl), fibroblast growth factor receptor 1 (fgfr1), fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) L homeolog (fgfr3.L), fibroblast growth factor receptor 1 (FGFR1), fibroblast growth factor receptor 1 (Fgfr1), Fibroblast growth factor receptor 1 (Fgfr1), fibroblast growth factor receptor 1 L homeolog (fgfr1.L), fibroblast growth factor receptor 1a (fgfr1a), ach, AW208770, bFGF-R-1, bfgfr, BFGFR, cb231, cd331, CD331, cd333, cek, CEK, cek2, CG7223, CT22273, CT39172, DFGF-R1, DFGF-R2, DFR-1, Dfr-1, DFR1, Dfr1, DFR1/DFGF-R2, Dmel\\CG7223, DmHD-38, DPR3, Dtk1, dtk1, DTRK(FR1), Eask, EMS2, FGF-R2, fgfbr, FGFBR, FGFR, fgfr, fgfr-1, FGFR-1, Fgfr-1, fgfr-3, fgfr1, FGFR2, FGFRI, flg, FLG, FLG-1, flt-2, FLT-2, Flt-2, flt2, FLT2, FR1, Fr1, hbgfr, HBGFR, HD-38, HH2, hsfgfr3ex, Hspy, Htl, HTL/FGFR1, i79, i100, i150, j372, jtk4, kal2, KAL2, n-sam, N-SAM, ogd, OGD, sb:cb231, Tk1, X1FGFR, x1fgfr, XFGFR-1, xfgfr1, XFGFRA2Protein level used designations for FGFR1
- fibroblast growth factor receptor
- FGFR-1
- fibroblast growth factor receptor-1
- basic fibroblast growth factor receptor 1
- CG7223-PA
- CG7223-PB
- CG7223-PC
- FGF receptor
- fibroblast growth factor receptor 1
- htl-PA
- htl-PB
- htl-PC
- fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
- ibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
- basic fibroblast growth factor receptor 1-like
- FGFR1/PLAG1 fusion
- FMS-like tyrosine kinase 2
- fms-related tyrosine kinase 2
- heparin-binding growth factor receptor
- hydroxyaryl-protein kinase
- proto-oncogene c-Fgr
- MFR
- bFGF-R-1
- c-fgr
- FGF receptor-1
- bFGF-R
- cek1 protein
- tyrosine kinase receptor CEK1
- FGFR-1-A
- bFGF-R-1-A
- basic fibroblast growth factor receptor 1-A
- fibroblast growth factor receptor 1-A
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