FEN1 Products
(Flap Structure-Specific Endonuclease 1 (FEN1))
Categories
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008].
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Featured FEN1 Categories
FEN1 Antibodies
High quality antibodies with extensive validation data.
FEN1 ELISA Kits
Reliable ELISA kits for a wide range of species.
FEN1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FEN1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IP, IHC (p), ICC, PLA
Validations
- (6)
Cat. No.
ABIN2855166
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IP
Validations
- (6)
Cat. No.
ABIN3021632
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7255764
Quantity
200 μL
Datasheet
Datasheet
Recommended FEN1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955927
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1133432
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6217033
Quantity
96 tests
Datasheet
Datasheet
Recommended FEN1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353954
Quantity
2 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353955
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN1096675
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our FEN1 products
: "Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response." in: International journal of biological sciences, Vol. 12, Issue 4, pp. 466-77, (2016) (PubMed).: "Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication." in: The Journal of biological chemistry, Vol. 287, Issue 26, pp. 21980-91, (2012) (PubMed).
: "Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function." in: Neoplasia (New York, N.Y.), Vol. 14, Issue 6, pp. 495-508, (2012) (PubMed).
: "Prostate cancer cell lines under hypoxia exhibit greater stem-like properties." in: PLoS ONE, Vol. 6, Issue 12, pp. e29170, (2012) (PubMed).
: "Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair." in: The Journal of biological chemistry, Vol. 286, Issue 37, pp. 31975-83, (2011) (PubMed).
: "Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity." in: Biochemistry, Vol. 50, Issue 11, pp. 1901-9, (2011) (PubMed).
: "DNA polymerase beta-dependent long patch base excision repair in living cells." in: DNA repair, Vol. 9, Issue 2, pp. 109-19, (2010) (PubMed).
: "FEN1 ensures telomere stability by facilitating replication fork re-initiation." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27057-66, (2010) (PubMed).
: "Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding." in: Nature chemical biology, Vol. 6, Issue 10, pp. 766-73, (2010) (PubMed).
: "Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance." in: The Journal of biological chemistry, Vol. 284, Issue 6, pp. 3682-90, (2009) (PubMed).
Synonyms and alternative names related to FEN1
flap structure-specific endonuclease 1 (FEN1), flap endonuclease 1-like (LOC100808044), Flap endonuclease-1 (Bm1_49605), 5'-3' exonuclease family protein (AT5G26680), flap structure specific endonuclease 1 (Fen1), flap structure-specific endonuclease 1 (fen1), flap structure-specific endonuclease 1 L homeolog (fen1.L), flap structure-specific endonuclease 1 (Fen1), nuclease, Rad2 family (FEN1), AW538437, cb879, FEN-1, fen-1, FEN1, fen1, MF1, mf1, RAD2, rad2, xFEN1aProtein level used designations for FEN1
- flap endonuclease 1
- Flap structure-specific endonuclease 1
- flap structure-specific endonuclease 1
- DNase IV
- maturation factor 1
- maturation factor-1
- 5' nuclease xFEN1a
- FEN-1-A
- flap endonuclease 1-A
- flap structure-specific endonuclease 1-A
- xFEN-1a
- FEN-1
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