FCGR3A Products
(Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))
Categories
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured FCGR3A Categories
FCGR3A Antibodies
High quality antibodies with extensive validation data.
FCGR3A ELISA Kits
Reliable ELISA kits for a wide range of species.
FCGR3A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FCGR3A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7158547
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN6261703
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN515572
Quantity
100 μg
Datasheet
Datasheet
Recommended FCGR3A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6955740
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730644
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1743247
Quantity
96 tests
Datasheet
Datasheet
Recommended FCGR3A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7274281
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7274282
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7536872
Quantity
250 μg
Datasheet
Datasheet
Latest Publications for our FCGR3A products
: "FcγR Binding and ADCC Activity of Human IgG Allotypes." in: Frontiers in immunology, Vol. 11, pp. 740, (2020) (PubMed).: "Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies." in: mAbs, Vol. 11, Issue 5, pp. 826-836, (2020) (PubMed).
: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
: "Identification of anti-CD16a single domain antibodies and their application in bispecific antibodies." in: Cancer biology & therapy, pp. 1-9, (2019) (PubMed).
: "Structural and functional characterization of MBS301, an afucosylated bispecific anti-HER2 antibody." in: mAbs, Vol. 10, Issue 6, pp. 864-875, (2019) (PubMed).
: "Charge variant analysis of proposed biosimilar to Trastuzumab." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 46, pp. 46-56, (2017) (PubMed).
: "Elevated Membrane and Soluble CD64: A Novel Marker Reflecting Altered Fc?R Function and Disease in Early Rheumatoid Arthritis That Can Be Regulated by Anti-Rheumatic Treatment." in: PLoS ONE, Vol. 10, Issue 9, pp. e0137474, (2015) (PubMed).
: "Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactions." in: Journal of proteome research, Vol. 13, Issue 12, pp. 5471-85, (2014) (PubMed).
: "T lymphocytes expressing a CD16 signaling receptor exert antibody-dependent cancer cell killing." in: Cancer research, Vol. 74, Issue 1, pp. 93-103, (2014) (PubMed).
: "Development of a cell-based assay measuring the activation of FcγRIIa for the characterization of therapeutic monoclonal antibodies." in: PLoS ONE, Vol. 9, Issue 4, pp. e95787, (2014) (PubMed).
Synonyms and alternative names related to FCGR3A
Fc fragment of IgG receptor IIIa (FCGR3A), Fc fragment of IgG receptor IIIa (Fcgr3a), CD16, CD16A, FCG3, FCGR3, Fcgr4, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3Protein level used designations for FCGR3A
- CD16a antigen
- Fc fragment of IgG, low affinity III, receptor for (CD16)
- Fc gamma receptor III-A
- Fc-gamma RIII-alpha
- Fc-gamma RIIIa
- Fc-gamma receptor III-2 (CD 16)
- Fc-gamma receptor IIIb (CD16)
- FcgammaRIIIA
- fc-gamma RIII
- igG Fc receptor III-2
- immunoglobulin G Fc receptor III
- low affinity immunoglobulin gamma Fc region receptor III-A
- neutrophil-specific antigen NA
- Fc fragment of IgG intermediate affinity IV receptor
- Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
- transmembrane receptor FcgammaRIII-X
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