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Fc Receptor, IgG, Low Affinity IV Proteins

(Fc Receptor, IgG, Low Affinity IV (FCGR4))

Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578). Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411, PubMed:18949059). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:16039578). Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719). Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059). Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059). {ECO:0000269|PubMed:16039578, ECO:0000269|PubMed:17558411, ECO:0000269|PubMed:18097064, ECO:0000269|PubMed:18949059, ECO:0000269|PubMed:19795417, ECO:0000269|PubMed:25824719}.

FCGR4 Origin: Mouse Host: Human Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE. ELISA, MS, SDS, WB

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Fc Receptor, IgG, Low Affinity IV Proteins by Origin

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Fc Receptor, IgG, Low Affinity IV Proteins by Source

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Fc Receptor, IgG, Low Affinity IV Proteins by Protein Type

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Fc Receptor, IgG, Low Affinity IV Proteins by Application

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Popular Fc Receptor, IgG, Low Affinity IV Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

Fc Receptor, IgG, Low Affinity IV (FCGR4) (AA 21-203) protein (His tag)

Reactivity Mouse

Source Human Cells

Validations

Cat. No. ABIN7314672

Quantity 50 μg

Datasheet Datasheet

Aliases for Fc Receptor, IgG, Low Affinity IV Proteins

Fc receptor, IgG, low affinity IV (Fcgr4) Proteins
4833442P21Rik Proteins
CD16-2 Proteins
FcgammaRIV Proteins
Fcgr3a Proteins
FcgRIV Proteins
Fcrl3 Proteins

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