FBXW7 Products
(F-Box and WD Repeat Domain Containing 7 (FBXW7))
Categories
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].
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Featured FBXW7 Categories
FBXW7 Antibodies
High quality antibodies with extensive validation data.
FBXW7 ELISA Kits
Reliable ELISA kits for a wide range of species.
FBXW7 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FBXW7 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (1)
- (7)
Cat. No.
ABIN2782955
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro)
Validations
- (2)
- (3)
Cat. No.
ABIN1386103
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (5)
- (3)
Cat. No.
ABIN527479
Quantity
100 μg
Datasheet
Datasheet
Recommended FBXW7 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1743138
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Sheep
Analytical Method
Validations
Cat. No.
ABIN1774043
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Dog
Analytical Method
Validations
Cat. No.
ABIN1769147
Quantity
96 tests
Datasheet
Datasheet
Recommended FBXW7 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353879
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1990130
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3092548
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our FBXW7 products
: "miR‑223‑3p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors." in: International journal of oncology, Vol. 50, Issue 2, pp. 356-364, (2016) (PubMed).: "Dysfunction of microRNA-32 regulates ubiquitin ligase FBXW7 in multiple myeloma disease." in: OncoTargets and therapy, Vol. 9, pp. 6573-6579, (2016) (PubMed).
: "F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner." in: The Journal of clinical investigation, Vol. 125, Issue 2, pp. 621-35, (2015) (PubMed).
: "RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway." in: Biochemical and biophysical research communications, Vol. 454, Issue 1, pp. 71-7, (2015) (PubMed).
: "Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway." in: International journal of oncology, Vol. 47, Issue 1, pp. 231-43, (2015) (PubMed).
: "Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length." in: The EMBO journal, Vol. 34, Issue 19, pp. 2424-40, (2015) (PubMed).
: "Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry." in: Cell death and differentiation, Vol. 22, Issue 11, pp. 1775-84, (2015) (PubMed).
: "FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC." in: Oncotarget, Vol. 6, Issue 14, pp. 12697-709, (2015) (PubMed).
: "STAT1 inhibits human hepatocellular carcinoma cell growth through induction of p53 and Fbxw7." in: Cancer cell international, Vol. 15, pp. 111, (2015) (PubMed).
: "FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs." in: Molecular cancer research : MCR, Vol. 12, Issue 1, pp. 32-7, (2014) (PubMed).
Synonyms and alternative names related to FBXW7
F-box and WD repeat domain containing 7 (Fbxw7), F-box and WD repeat domain containing 7 (FBXW7), F-box and WD repeat domain containing 7 (fbxw7), F-box and WD-40 domain protein 7 (Fbxw7), 1110001A17Rik, AGO, cdc4, CDC4, Cdc4, FBW6, FBW7, Fbw7, Fbwd6, FBX30, Fbx30, FBXO30, Fbxo30, FBXW6, Fbxw6, hAgo, hCdc4, SEL-10, SEL10Protein level used designations for FBXW7
- F-box and WD-40 domain protein 7
- F-box/WD repeat-containing protein 7
- F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
- F-box protein FBW7
- F-box protein FBX30
- F-box protein SEL-10
- archipelago
- homolog of C elegans sel-10
- F-box and WD-40 domain protein 7, archipelago homolog
- F-box and WD-40 domain-containing protein 7
- F-box protein Fbxw6
- F-box-WD40 repeat protein 6
- f-box only protein 30
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