FBXO11 Products
(F-Box Protein 11 (FBXO11))
Categories
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010].
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Featured FBXO11 Categories
FBXO11 Antibodies
High quality antibodies with extensive validation data.
FBXO11 ELISA Kits
Reliable ELISA kits for a wide range of species.
FBXO11 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FBXO11 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (4)
Cat. No.
ABIN566432
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN1386847
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN7261998
Quantity
200 μL
Datasheet
Datasheet
Recommended FBXO11 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Sheep
Analytical Method
Validations
Cat. No.
ABIN1773981
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1743076
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Dog
Analytical Method
Validations
Cat. No.
ABIN1769085
Quantity
96 tests
Datasheet
Datasheet
Recommended FBXO11 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353767
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3089172
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3121953
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our FBXO11 products
: "Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs." in: Molecular cell, Vol. 74, Issue 6, pp. 1264-1277.e7, (2019) (PubMed).: "Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing." in: Nature cell biology, Vol. 17, Issue 1, pp. 31-43, (2014) (PubMed).
: "DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation." in: Developmental cell, Vol. 28, Issue 6, pp. 697-710, (2014) (PubMed).
: "Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase." in: Molecular cell, Vol. 49, Issue 6, pp. 1159-66, (2013) (PubMed).
: "FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas." in: Nature, Vol. 481, Issue 7379, pp. 90-3, (2012) (PubMed).
: "Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 1, pp. 100-5, (2008) (PubMed).
Synonyms and alternative names related to FBXO11
F-box protein 11 (FBXO11), F-box protein 11 (Fbxo11), F-box protein 11 L homeolog (fbxo11.L), F-box protein 11a (fbxo11a), F-box only protein 11 (CpipJ_CPIJ009919), F-box only protein 11 (CpipJ_CPIJ017549), F-box only protein 11 (Bm1_52225), hypothetical protein (LOAG_16571), F-box protein 11 (fbxo11), F-box protein 11 (LOC100115478), C80048, DKFZp459P2410, FBX11, fbxo11, FBXO11, Fbxo11, im:6906507, Jf, MGC84634, PRMT9, UBR6, VIT1, Vit1, wu:fj83f06, zgc:153171Protein level used designations for FBXO11
- F-box only protein 11
- protein arginine N-methyltransferase 9
- ubiquitin protein ligase E3 component n-recognin 6
- vitiligo-associated protein 1
- vitiligo-associated protein VIT-1
- GENA 104
- jeff
- F-box protein 11
- fj83f06
- F-box only protein 11-like
- f-box only protein 11-like
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