F12 Products
(Coagulation Factor XII (F12))
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This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008].
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Featured F12 Categories
F12 Antibodies
High quality antibodies with extensive validation data.
F12 ELISA Kits
Reliable ELISA kits for a wide range of species.
F12 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended F12 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7432373
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7432376
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IHC, ICC, IF
Validations
- (3)
Cat. No.
ABIN6261640
Quantity
100 μL
Datasheet
Datasheet
Recommended F12 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954882
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965907
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965909
Quantity
96 tests
Datasheet
Datasheet
Recommended F12 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353303
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353299
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7391612
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our F12 products
: "Neutralizing blood-borne polyphosphate in vivo provides safe thromboprotection." in: Nature communications, Vol. 7, pp. 12616, (2018) (PubMed).: "Ex vivo simulation of cardiopulmonary bypass with human blood for hemocompatibility testing." in: Perfusion, Vol. 31, Issue 5, pp. 376-83, (2016) (PubMed).
: "β-Eliminative depolymerization of the fucosylated chondroitin sulfate and anticoagulant activities of resulting fragments." in: Carbohydrate polymers, Vol. 127, pp. 427-37, (2015) (PubMed).
: "A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation." in: ACS chemical biology, Vol. 10, Issue 8, pp. 1861-70, (2015) (PubMed).
: "Proteomic profiles in acute respiratory distress syndrome differentiates survivors from non-survivors." in: PLoS ONE, Vol. 9, Issue 10, pp. e109713, (2014) (PubMed).
: "Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides." in: Nucleic acids research, Vol. 42, Issue 22, pp. e169, (2014) (PubMed).
: "Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model." in: Proteome science, Vol. 9, pp. 73, (2011) (PubMed).
: "Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment." in: Blood, Vol. 112, Issue 9, pp. 3555-62, (2008) (PubMed).
: "Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation." in: The Journal of clinical investigation, Vol. 118, Issue 9, pp. 3208-18, (2008) (PubMed).
: "The elusive physiologic role of Factor XII." in: The Journal of clinical investigation, Vol. 118, Issue 9, pp. 3006-9, (2008) (PubMed).
Synonyms and alternative names related to F12
coagulation factor XII (F12), coagulation factor XII (Hageman factor) (F12), FXII, HAE3, HAEX, HAFProtein level used designations for F12
- Hageman factor
- beta-factor XIIa part 1
- beta-factor XIIa part 2
- coagulation factor XII
- coagulation factor XIIa heavy chain
- coagulation factor XIIa light chain
- factor XII
- hageman factor
- HAF
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