FANCL Products
(Fanconi Anemia, Complementation Group L (FANCL))
Categories
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured FANCL Categories
FANCL Antibodies
High quality antibodies with extensive validation data.
FANCL ELISA Kits
Reliable ELISA kits for a wide range of species.
FANCL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FANCL Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (6)
Cat. No.
ABIN949415
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN7262741
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7151021
Quantity
100 μg
Datasheet
Datasheet
Recommended FANCL ELISA Kits
Recommended FANCL Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353638
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells, Insect cells (Sf9)
Validations
Cat. No.
ABIN6699823
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our FANCL products
: "Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate." in: Oncotarget, Vol. 5, Issue 5, pp. 1326-37, (2014) (PubMed).: "FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth." in: The Journal of clinical investigation, Vol. 120, Issue 5, pp. 1524-34, (2010) (PubMed).
: "Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer ..." in: Carcinogenesis, Vol. 30, Issue 11, pp. 1898-902, (2009) (PubMed).
: "FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL." in: The Journal of biological chemistry, Vol. 284, Issue 35, pp. 23182-6, (2009) (PubMed).
: "Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 9, pp. 2549-52, (2009) (PubMed).
: "Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia." in: Cellular oncology : the official journal of the International Society for Cellular Oncology, Vol. 30, Issue 4, pp. 299-306, (2008) (PubMed).
Synonyms and alternative names related to FANCL
Fanconi anemia complementation group L (FANCL), Fanconi anemia, complementation group L (Fancl), 2010322C19Rik, AW554273, B230118H11Rik, FAAP43, gcd, PHF9, Phf9, POG, PogProtein level used designations for FANCL
- E3 ubiquitin-protein ligase FANCL
- PHD finger protein 9
- fanconi anemia group L protein
- fanconi anemia-associated polypeptide of 43 kDa
- fanconi anemia group L protein homolog
- germ cell deficient
- proliferation of germ cells protein
Did you look for something else?
- FANCI
- FANCG
- FANCF
- FANCE
- FANCD2
- FANCC
- FANCB
- FANCA
- FAN1
- Family with Sequence Similarity 92, Member A1
- Family with Sequence Similarity 69, Member C
- Family with Sequence Similarity 58, Member B
- Family with Sequence Similarity 50, Member A
- Family with Sequence Similarity 46, Member B
- Family with Sequence Similarity 220, Member A
- Family with Sequence Similarity 212, Member A
- Family with Sequence Similarity 21, Member B
- Family with Sequence Similarity 102, Member B
- Family with Sequence Similarity 102, Member A
- FAM9C
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