FADD Products
(Fas (TNFRSF6)-Associated Via Death Domain (FADD))
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The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008].
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Featured FADD Categories
FADD Antibodies
High quality antibodies with extensive validation data.
FADD ELISA Kits
Reliable ELISA kits for a wide range of species.
FADD Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FADD Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7439960
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (1)
- (4)
Cat. No.
ABIN6140432
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (4)
Cat. No.
ABIN7193411
Quantity
100 μL
Datasheet
Datasheet
Recommended FADD ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966647
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955701
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380874
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended FADD Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1353355
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN667076
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353353
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our FADD products
: "Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration." in: Journal of diabetes and its complications, Vol. 33, Issue 9, pp. 668-674, (2019) (PubMed).: "Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway." in: The international journal of biochemistry & cell biology, Vol. 99, pp. 169-177, (2018) (PubMed).
: "15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo." in: Frontiers in pharmacology, Vol. 9, pp. 25, (2018) (PubMed).
: "D4F alleviates macrophage-derived foam cell apoptosis by inhibiting the NF-κB-dependent Fas/FasL pathway." in: Scientific reports, Vol. 7, Issue 1, pp. 7333, (2017) (PubMed).
: "Early septic insult in neonatal pigs increases serum and urinary soluble Fas ligand and decreases kidney function without inducing significant renal apoptosis." in: Renal failure, pp. 1-12, (2016) (PubMed).
: "FADD-calmodulin interaction: a novel player in cell cycle regulation." in: Biochimica et biophysica acta, Vol. 1803, Issue 8, pp. 898-911, (2010) (PubMed).
: "Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22713-22, (2010) (PubMed).
: "Lack of Fas-pathway gene mutations in primary resected esophageal squamous cell carcinoma." in: Chang Gung medical journal, Vol. 33, Issue 2, pp. 145-51, (2010) (PubMed).
: "Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6306-16, (2010) (PubMed).
: "Dengue hemorrhagic fever is associated with polymorphisms in JAK1." in: European journal of human genetics : EJHG, Vol. 18, Issue 11, pp. 1221-7, (2010) (PubMed).
Synonyms and alternative names related to FADD
Fas associated via death domain (FADD), Fas (TNFRSF6)-associated via death domain (Fadd), Fas associated via death domain (Fadd), Fas associated via death domain S homeolog (fadd.S), Fas (tnfrsf6)-associated via death domain (fadd), adaptor, fadd, MORT1, Mort1, mort1, Mort1/FADD, TNFRSF6, xfaddProtein level used designations for FADD
- Fas-associating death domain-containing protein
- Fas-associating protein with death domain
- growth-inhibiting gene 3 protein
- mediator of receptor induced toxicity
- mediator of receptor-induced toxicity
- protein FADD
- FAS-associated death domain protein
- FAS-associating death domain-containing protein
- Fas (TNF receptor superfamily, member 6)
- Fas-associated via death domain
- Fas (TNFRSF6)-associated via death domain
- Fas associated via death domain S homeolog
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