EWSR1 Products
(Ewing Sarcoma Breakpoint Region 1 (EWSR1))
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This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009].
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Featured EWSR1 Categories
EWSR1 Antibodies
High quality antibodies with extensive validation data.
EWSR1 ELISA Kits
Reliable ELISA kits for a wide range of species.
EWSR1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended EWSR1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (6)
Cat. No.
ABIN335135
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (4)
Cat. No.
ABIN560815
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN2779045
Quantity
100 μL
Datasheet
Datasheet
Recommended EWSR1 ELISA Kits
Recommended EWSR1 Proteins
Latest Publications for our EWSR1 products
: "Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)." in: Nature communications, Vol. 6, pp. 8088, (2015) (PubMed).: "Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS." in: Biochemical and biophysical research communications, Vol. 426, Issue 1, pp. 89-93, (2012) (PubMed).
: "Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A." in: Cancer research, Vol. 66, Issue 11, pp. 5574-81, (2006) (PubMed).
: "Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers." in: Cancer cell, Vol. 9, Issue 6, pp. 473-84, (2006) (PubMed).
Synonyms and alternative names related to EWSR1
EWS RNA binding protein 1 (EWSR1), Ewing sarcoma breakpoint region 1 (Ewsr1), EWS RNA-binding protein 1 (Ewsr1), EWS RNA-binding protein 1a (ewsr1a), EWS RNA binding protein 1 (ewsr1), EWS RNA binding protein 1 (Ewsr1), EWS RNA binding protein 1 L homeolog (ewsr1.L), EWS RNA-binding protein 1b (ewsr1b), AU018891, bK984G1.4, DKFZp459K1116, EWS, Ews, Ewsh, EWSR1, ewsr1, ewsr1.S, fb40b11, fc04c01, fusl, wu:fb40b11, wu:fb75g09, wu:fc04c01, zgc:55864Protein level used designations for EWSR1
- Ewing sarcoma breakpoint region 1
- Ewings sarcoma EWS-Fli1 (type 1) oncogene
- RNA-binding protein EWS
- Ewing sarcoma homolog
- Ewing sarcoma RNA-binding protein
- EWS RNA binding protein 1 S homeolog
- uncharacterized protein LOC734969
- Ewing sarcoma breakpoint region 1b
- fusion, derived from t(12;16) malignant liposarcoma, like
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